Subtle alterations in cerebrovascular reactivity in mild cognitive impairment detected by graph theoretical analysis and not by the standard approach.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_7FF87904E1DF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Subtle alterations in cerebrovascular reactivity in mild cognitive impairment detected by graph theoretical analysis and not by the standard approach.
Périodique
NeuroImage. Clinical
Auteur(s)
Sánchez-Catasús C.A., Sanabria-Diaz G., Willemsen A., Martinez-Montes E., Samper-Noa J., Aguila-Ruiz A., Boellaard R., De Deyn P., Dierckx RAJO, Melie-Garcia L.
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
15
Pages
151-160
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
There is growing support that cerebrovascular reactivity (CVR) in response to a vasodilatory challenge, also defined as the cerebrovascular reserve, is reduced in Alzheimer's disease dementia. However, this is less clear in patients with mild cognitive impairment (MCI). The current standard analysis may not reflect subtle abnormalities in CVR. In this study, we aimed to investigate vasodilatory-induced changes in the topology of the cerebral blood flow correlation (CBF javax.xml.bind.JAXBElement@6894b36 ) network to study possible network-related CVR abnormalities in MCI. For this purpose, four CBF javax.xml.bind.JAXBElement@389286d6 networks were constructed: two using CBF SPECT data at baseline and under the vasodilatory challenge of acetazolamide (ACZ), obtained from a group of 26 MCI patients; and two equivalent networks from a group of 26 matched cognitively normal controls. The mean strength of association ( javax.xml.bind.JAXBElement@58a7138c ) and clustering coefficient ( javax.xml.bind.JAXBElement@5f56d60d ) were used to evaluate ACZ-induced changes on the topology of CBF javax.xml.bind.JAXBElement@13cae62a networks. We found that cognitively normal adults and MCI patients show different patterns of javax.xml.bind.JAXBElement@3fc266b3 and javax.xml.bind.JAXBElement@5f9929b4 changes. The observed differences included the medial prefrontal cortices and inferior parietal lobe, which represent areas involved in MCI's cognitive dysfunction. In contrast, no substantial differences were detected by standard CVR analysis. These results suggest that graph theoretical analysis of ACZ-induced changes in the topology of the CBF javax.xml.bind.JAXBElement@36167af4 networks allows the identification of subtle network-related CVR alterations in MCI, which couldn't be detected by the standard approach.

Mots-clé
Aged, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/physiopathology, Female, Humans, Male, Middle Aged, Neurovascular Coupling/physiology, Tomography, Emission-Computed, Single-Photon, Cerebrovascular reactivity, Graph theoretical, Mild cognitive impairment
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/05/2017 17:24
Dernière modification de la notice
20/08/2019 15:40
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