Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza.

Détails

ID Serval
serval:BIB_7FDC0E2B50E3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza.
Périodique
Immunity and Ageing : I and A
Auteur(s)
Aspinall R., Govind S., Lapenna A., Lang P.O.
ISSN
1742-4933 (Electronic)
ISSN-L
1742-4933
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
10
Numéro
1
Pages
34
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
Transfusion of autologous leukocytes after prolonged storage has been proposed as a means of rejuvenating the immune system of older individuals. The rationale for this approach is that age related immune decline is associated with a diminished pool of naïve T cells following atrophy of the thymus and reduction in thymic output. The presence of high levels of naïve T cells within the blood of young individuals could provide a boost to the immune system of an older "self" through a rejuvenation of the naïve T cell pool. However what remains unresolved is whether the cells could be incorporated effectively into the T cell pool of the host and whether effectors could be generated. Using CD45 congenic mice in our experiments we show that the transfusion of young donor cells into older congenic host animals leads to their successful incorporation into the peripheral T cell pool. When the recipients were challenged with influenza virus, specific effector CD8 cells were generated which were of both host and donor origin. We found no relationship between the number of responder cells of donor origin at the time of assay and the number of cells injected.
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/04/2015 8:11
Dernière modification de la notice
20/08/2019 14:40
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