Leukemoid Reaction in Infant Pertussis: Is There a Place for Hydroxyurea? A Case Report.

Détails

Ressource 1Télécharger: Leukemoid Reaction in Infant Pertussis: Is There a Place for Hydroxyurea_A Case Report_FrontPediatr2018.pdf (580.14 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_7FD3A304D580
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Leukemoid Reaction in Infant Pertussis: Is There a Place for Hydroxyurea? A Case Report.
Périodique
Frontiers in pediatrics
Auteur(s)
Maitre G., Schaffner D., Natterer J., Longchamp D., Ferry T., Diezi M., Di Bernardo S., Perez M.H., Amiet V.
ISSN
2296-2360 (Print)
ISSN-L
2296-2360
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
6
Pages
261
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
A 73-days old infant of 34 weeks' gestation was hospitalized with a co-infection of respiratory syncytial virus (RSV) and <i>Bordetella pertussis (BP)</i> . She required invasive ventilation for 9 days in the context of malignant pertussis with persistent hypoxemia and hypercapnia secondary to a leukemoid reaction. Despite an increase of white blood cell (WBC) count up to 70 G/L and ensuing pulmonary hypertension, no hemodynamic compromise occurred. Without clear indication for leukapheresis nor exchange transfusion, an off-label treatment with hydroxyurea was given for 5 days with gradual decrease of WBC count, without any complication and hospital discharge on day 29. To our knowledge, no effective therapy for malignant pertussis has been described in the literature and complications are frequent with leukoreduction procedures. We discuss an alternative to invasive procedures in young infants to fulfill the need to decrease rapidly leukocyte counts in a leukemoid reaction associated with <i>Bordetella pertussis</i> infection. To our knowledge, hydroxyurea has never been used in malignant pertussis but is a well-known medication for oncologic and hematologic diseases such as acute myeloid leukemia or sickle cell anemia. Its effects in this setting are not well understood but the positive outcome in our patient supports the need for further studies.
Mots-clé
bordetella pertussis, hydroxyurea, hyperleukocytosis, leukemoid reaction, white blood cell count
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/10/2018 16:48
Dernière modification de la notice
20/08/2019 14:40
Données d'usage