Genetic hypercalciuria.

Détails

ID Serval
serval:BIB_7F6B2E2522FE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Genetic hypercalciuria.
Périodique
Journal of the American Society of Nephrology
Auteur⸱e⸱s
Moe O.W., Bonny O.
ISSN
1046-6673 (Print)
ISSN-L
1046-6673
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
16
Numéro
3
Pages
729-745
Langue
anglais
Résumé
Hypercalciuria is an important, identifiable, and reversible risk factor in stone formation. The foremost and most fundamental step in dissecting the genetics of hypercalciuria is understanding its pathophysiology. Hypercalciuria is a complex trait. This article outlines the various factors that compromise the attempt to dissect the genetics of hypercalciuria, summarizes the clinical and experimental monogenic causes of hypercalciuria, and outlines the initial results from attempts in studying polygenic hypercalciuria. Finally, the problem is set in perspective of the current database, technologic advances and limitations are highlighted, and prospects of further advances in the field are speculated upon.
Mots-clé
Animals, Calcium/urine, Calcium Metabolism Disorders/genetics, Calcium Metabolism Disorders/physiopathology, Humans, Kidney Calculi/genetics, Kidney Calculi/physiopathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/02/2010 11:18
Dernière modification de la notice
20/08/2019 14:40
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