Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.

Détails

ID Serval
serval:BIB_7F67051E5415
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients.
Périodique
Journal of Hepatology
Auteur⸱e⸱s
Sarrazin C., Susser S., Doehring A., Lange C.M., Müller T., Schlecker C., Herrmann E., Lötsch J., Berg T.
ISSN
1600-0641 (Electronic)
ISSN-L
0168-8278
Statut éditorial
Publié
Date de publication
2011
Volume
54
Numéro
3
Pages
415-421
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND & AIMS: Genetic variation in the interleukin 28B (IL28B) gene has been associated with the response to interferon-alfa/ribavirin therapy in hepatitis C virus (HCV) genotype 1-infected patients. The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown.
METHODS: In patients with chronic hepatitis C genotype 2/3 (n=267), IL28B host genotypes (rs8099917, rs12980275 and rs12979860) were analyzed for associations with sustained virologic response (SVR) to antiviral therapy with (pegylated) interferon-alfa and ribavirin and with respect to epidemiological, biochemical, and virological parameters. For comparison, hepatitis C genotype 1 patients (n=378) and healthy controls (n=200) were included.
RESULTS: The rs12979860 CC genotype, lower age, and genotype 2 were significantly associated with SVR in HCV genotype 2/3-infected patients (p=0.01, p=0.03 and p=0.03, respectively). No association was observed for rs8099917 and rs12980275. In addition, an SVR in patients with rapid virologic response (RVR) was associated with the rs12979860 CC genotype (p=0.05), while for non-RVR no association was found. Furthermore, a significant association with a higher baseline viral load was observed for all three IL28B genotypes in genotype 1/2/3-infected patients. Finally, increasing frequencies of the rs12979860 CC genotypes were observed in genotype 1- (33.9%), genotype 3- (38.9%), and genotype 2-infected (51.9%) patients in comparison with healthy controls (49.0%) (p<0.01).
CONCLUSIONS: In genotype 2/3-infected patients, rs12979860 was significantly associated with SVR. The frequency of the rs12979860 CC genotype is lower in HCV genotype 1 vs. genotype 2/3 patients. All major IL28B genotypes are associated with HCV-RNA concentration.
Mots-clé
Adult, Alanine Transaminase/blood, Alleles, Antiviral Agents/therapeutic use, Base Sequence, Case-Control Studies, DNA Primers/genetics, Female, Gene Frequency, Genotype, Germany, Hepacivirus/classification, Hepacivirus/drug effects, Hepatitis C, Chronic/drug therapy, Hepatitis C, Chronic/genetics, Humans, Interferon Type I/therapeutic use, Interleukins/genetics, Male, Middle Aged, Polymorphism, Single Nucleotide, RNA, Viral/blood, RNA, Viral/genetics, Recombinant Proteins, Ribavirin/therapeutic use, Viral Load
Pubmed
Web of science
Création de la notice
02/02/2011 14:27
Dernière modification de la notice
20/08/2019 14:40
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