The Eye on Mitochondrial Disorders.

Détails

Ressource 1Télécharger: BIB_7F3ABF62D193.P001.pdf (1095.98 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_7F3ABF62D193
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Eye on Mitochondrial Disorders.
Périodique
Journal of Child Neurology
Auteur(s)
Finsterer J., Zarrouk-Mahjoub S., Daruich A.
ISSN
1708-8283 (Electronic)
ISSN-L
0883-0738
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
31
Numéro
5
Pages
652-662
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Ophthalmologic manifestations of mitochondrial disorders are frequently neglected or overlooked because they are often not regarded as part of the phenotype. This review aims at summarizing and discussing the etiology, pathogenesis, diagnosis, and treatment of ophthalmologic manifestations of mitochondrial disorders. Review of publications about ophthalmologic involvement in mitochondrial disorders by search of Medline applying appropriate search terms. The eye is frequently affected by syndromic as well as nonsyndromic mitochondrial disorders. Primary and secondary ophthalmologic manifestations can be differentiated. The most frequent ophthalmologic manifestations of mitochondrial disorders include ptosis, progressive external ophthalmoplegia, optic atrophy, retinopathy, and cataract. More rarely occurring are nystagmus and abnormalities of the cornea, ciliary body, intraocular pressure, the choroidea, or the brain secondarily affecting the eyes. It is important to recognize and diagnose ophthalmologic manifestations of mitochondrial disorders as early as possible because most are accessible to symptomatic treatment with partial or complete short-term or long-term beneficial effect. Ophthalmologic manifestations of mitochondrial disorders need to be appropriately diagnosed to initiate the most effective management and guarantee optimal outcome.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/02/2016 17:24
Dernière modification de la notice
20/08/2019 14:40
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