Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.

Détails

ID Serval
serval:BIB_7F20C2444944
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.
Périodique
Mechanisms of ageing and development
Auteur(s)
Giuliani Cristina, Pirazzini Chiara, Delledonne Massimo, Xumerle Luciano, Descombes Patrick, Marquis Julien, Mengozzi Giacomo, Monti Daniela, Bellizzi Dina, Passarino Giuseppe, Luiselli Donata, Franceschi Claudio, Garagnani Paolo
Statut éditorial
Publié
Date de publication
07/2017
Volume
165
Numéro
Pt B
Pages
195-201
Langue
anglais
Résumé
In this review, we address the genetic continuum between aging and age-related diseases, with particular attention to the ecological perspective. We describe the connections between genes that promote longevity and genes associated with age-related diseases considering tradeoff mechanisms in which the same genetic variants could have different effects according to the tissue considered and could be involved in several biological pathways. Then we describe mechanisms of antagonistic pleiotropy, focusing on the complex interplay between genetic variants and environmental changes (internal or external). We sustain the use of centenarians as "super-controls" for the study of the major age-related diseases, starting from the concept that the maximization of the phenotypic differences in the considered cohort, achieved by selecting the most divergent phenotypes, could be useful for increasing the significant differences observed in the genetic association study. We describe the potential impact of the population genetic variability in the study of human longevity and the possible contribution of the past selective pressures in shaping the current genomic background of individuals. In conclusion, we illustrate recent findings emerged from whole-genome sequencing of long-lived individuals and future perspectives for interpreting the huge amount of genetic data that will be generated in the next future.
Mots-clé
Humans, Female, Male, *Age-related diseases, *Extreme phenotypes, *Gene-Environment Interaction, *Gene-environment interactions, *Genetic Variation, *Longevity, *Phenotype, *Populations, Aged, 80 and over, Genome-Wide Association Study, Longevity/*genetics
Pubmed
Création de la notice
19/02/2020 12:23
Dernière modification de la notice
19/06/2020 5:26
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