Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.

Détails

ID Serval
serval:BIB_7F0C100B4E19
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.
Périodique
Journal of mass spectrometry : JMS
Auteur(s)
Kostiainen R., Kotiaho T., Kuuranne T., Auriola S.
ISSN
1076-5174 (Print)
ISSN-L
1076-5174
Statut éditorial
Publié
Date de publication
04/2003
Peer-reviewed
Oui
Volume
38
Numéro
4
Pages
357-372
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The study of the metabolic fate of drugs is an essential and important part of the drug development process. The analysis of metabolites is a challenging task and several different analytical methods have been used in these studies. However, after the introduction of the atmospheric pressure ionization (API) technique, electrospray and atmospheric pressure chemical ionization, liquid chromatography/mass spectrometry (LC/MS) has become an important and widely used method in the analysis of metabolites owing to its superior specificity, sensitivity and efficiency. In this paper the feasibility of LC/API-MS techniques in the identification, structure characterization and quantitation of drug metabolites is reviewed. Sample preparation, LC techniques, isotope labeling, suitability of different MS techniques, such as tandem mass spectrometry, and high-resolution MS in drug metabolite analysis, are summarized and discussed. Automation of data acquisition and interpretation, special techniques and possible future trends are also the topics of the review.

Mots-clé
Atmospheric Pressure, Biotransformation, Chromatography, Liquid/methods, Humans, Mass Spectrometry/methods, Molecular Structure, Pharmaceutical Preparations/chemistry, Pharmaceutical Preparations/metabolism
Pubmed
Web of science
Création de la notice
02/05/2017 13:53
Dernière modification de la notice
20/08/2019 14:39
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