The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients.

Détails

ID Serval
serval:BIB_7F06912C80CF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients.
Périodique
Aids (london, England)
Auteur(s)
Bibert S., Wojtowicz A., Taffé P., Manuel O., Bernasconi E., Furrer H., Günthard H.F., Hoffmann M., Kaiser L., Osthoff M., Cavassini M., Bochud P.Y.
Collaborateur(s)
Swiss HIV Cohort Study
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
28
Numéro
13
Pages
1885-1889
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish IUMSP2014/08
Résumé
BACKGROUND: Cytomegalovirus (CMV) retinitis is a major cause of visual impairment and blindness among patients with uncontrolled HIV infections. Whereas polymorphisms in interferon-lambda 3 (IFNL3, previously named IL28B) strongly influence the clinical course of hepatitis C, few studies examined the role of such polymorphisms in infections due to viruses other than hepatitis C virus.
OBJECTIVES: To analyze the association of newly identified IFNL3/4 variant rs368234815 with susceptibility to CMV-associated retinitis in a cohort of HIV-infected patients.
DESIGN AND METHODS: This retrospective longitudinal study included 4884 white patients from the Swiss HIV Cohort Study, among whom 1134 were at risk to develop CMV retinitis (CD4 nadir <100 /μl and positive CMV serology). The association of CMV-associated retinitis with rs368234815 was assessed by cumulative incidence curves and multivariate Cox regression models, using the estimated date of HIV infection as a starting point, with censoring at death and/or lost follow-up.
RESULTS: A total of 40 individuals among 1134 patients at risk developed CMV retinitis. The minor allele of rs368234815 was associated with a higher risk of CMV retinitis (log-rank test P = 0.007, recessive mode of inheritance). The association was still significant in a multivariate Cox regression model (hazard ratio 2.31, 95% confidence interval 1.09-4.92, P = 0.03), after adjustment for CD4 nadir and slope, HAART and HIV-risk groups.
CONCLUSION: We reported for the first time an association between an IFNL3/4 polymorphism and susceptibility to AIDS-related CMV retinitis. IFNL3/4 may influence immunity against viruses other than HCV.
Mots-clé
AIDS, cytomegalovirus retinitis, HIV, IFNL3, immunogenetics, polymorphism
Pubmed
Web of science
Création de la notice
18/10/2014 16:51
Dernière modification de la notice
20/08/2019 14:39
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