American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response.

Détails

ID Serval
serval:BIB_7ED4EE289EE9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response.
Périodique
Clinical Infectious Diseases
Auteur(s)
Delobel P., Launois P., Djossou F., Sainte-Marie D., Pradinaud R.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Statut éditorial
Publié
Date de publication
2003
Volume
37
Numéro
5
Pages
628-633
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Cutaneous leishmaniasis, leprosy, and tuberculosis are caused by intracellular pathogens whose development depends on impaired cell-mediated immunity. We report an exceptional triple association of American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis in a man with no recognized immunodeficiency. Normal immunological assessment of the interferon-gamma pathway does not support the hypothesis of a genetic defect in any of the genes involved in the T helper (Th)-1 cytokine cascade in this patient. Unresponsiveness to interleukin (IL)-12 of his T cells after stimulation with Leishmania guyanensis, Mycobacterium bovis bacille Calmette-Guérin, and Mycobacterium leprae antigens suggested the inability to mount an appropriate Th cell response to upregulate the IL-12 receptor expression.
Mots-clé
Adult, Animals, Brazil, Down-Regulation/immunology, French Guiana, Humans, Leishmania guyanensis/drug effects, Leishmania guyanensis/immunology, Leishmaniasis, Cutaneous/blood, Leishmaniasis, Cutaneous/complications, Leprosy, Lepromatous/blood, Leprosy, Lepromatous/complications, Male, Mycobacterium leprae/drug effects, Mycobacterium leprae/immunology, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/immunology, Radiography, Thoracic, Receptors, Interleukin/biosynthesis, Receptors, Interleukin-12, T-Lymphocyte Subsets/immunology, Th1 Cells/immunology, Tuberculosis, Pulmonary/blood, Tuberculosis, Pulmonary/diagnosis
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 11:06
Dernière modification de la notice
20/08/2019 14:39
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