Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus

Détails

ID Serval
serval:BIB_7ECA23520EA8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus
Périodique
Neurochemical Research
Auteur(s)
Pellerin  L., Wolfe  L. S.
ISSN
0364-3190 (Print)
Statut éditorial
Publié
Date de publication
09/1991
Volume
16
Numéro
9
Pages
983-9
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
In hippocampal slices arachidonic acid released after NMDA post-synaptic receptor activation is thought to act as a retrograde trans-synaptic messenger which facilitates the pre-synaptic release of L-glutamate to be involved in the expression of long-term synaptic potentiation (LTP). We measured the mass amount of arachidonic acid released from hippocampal slices incubated under conditions which maintain the electrophysiological responsiveness of the slice. Melittin released arachidonic, oleic and docosahexaenoic acids by phospholipase A2 activation but not palmitic or stearic acids. Of greater interest L-glutamate, N-methyl-D-aspartate and incubation conditions known to induce LTP selectively and rapidly increased the release of arachidonic acid in amounts over basal levels of 200-300 ng/mg protein. This is the first direct determination of the mass amount of arachidonic acid released following NMDA receptor activation in the hippocampus.
Mots-clé
Animals Arachidonic Acid/*metabolism Electric Stimulation Fatty Acids/metabolism Glutamates Glutamic Acid Hippocampus/*drug effects/metabolism Male Melitten/pharmacology N-Methylaspartate Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate/*drug effects Synapses/*drug effects/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 13:16
Dernière modification de la notice
20/08/2019 14:39
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