Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females.

Détails

Ressource 1Télécharger: Serval_Postprint_Ofori_Clinical Endocrinology_2018.pdf (490.19 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_7EA748B2CAF8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females.
Périodique
Clinical endocrinology
Auteur(s)
Ofori E.K., Conde Alonso S., Correas-Gomez L., Carnero E.A., Zwygart K., Hugues H., Bardy D., Hans D., Dwyer A.A., Amati F.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Statut éditorial
Publié
Date de publication
03/2019
Peer-reviewed
Oui
Volume
90
Numéro
3
Pages
433-439
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women.
Observational, cross-sectional study of healthy, community dwelling postmenopausal women.
Postmenopausal women (60-80 years old) were included in this study. Overall body composition was evaluated by dual-energy X-ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography-tandem mass spectrometry.
Thirty-five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05).
Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.
Mots-clé
Abdominal Fat, Adiposity, Aged, Cross-Sectional Studies, Female, Humans, Middle Aged, Postmenopause/blood, Testosterone/blood, Thigh, body composition, intermuscular adipose tissue, regional adiposity, sexual dimorphism, superficial adipose tissue, visceral adipose tissue
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse / Projets / 320030_170062
Fonds national suisse / Carrières / PZ00P3-149398
Fonds national suisse / Carrières / PZ00P3-126339
Création de la notice
27/12/2018 10:48
Dernière modification de la notice
27/04/2020 5:20
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