Peripheral T-cell lymphoma with follicular involvement and a CD4+/bcl-6+ phenotype.

Détails

ID Serval
serval:BIB_7E8B7120F63C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Peripheral T-cell lymphoma with follicular involvement and a CD4+/bcl-6+ phenotype.
Périodique
American Journal of Surgical Pathology
Auteur⸱e⸱s
de Leval L., Savilo E., Longtine J., Ferry J.A., Harris N.L.
ISSN
0147-5185[print], 0147-5185[linking]
Statut éditorial
Publié
Date de publication
2001
Volume
25
Numéro
3
Pages
395-400
Langue
anglais
Résumé
A truly follicular pattern is thought to be restricted to B-cell lymphomas. We observed a prominent follicular growth pattern in three cases of nodal peripheral T-cell lymphomas, of which two were initially diagnosed as follicular lymphomas. All three patients were male, ranged in age from 50 to 70 years, and had generalized lymphadenopathy at the time of diagnosis. The follicles were sharply demarcated in two cases and large and vague in one case; in all cases, they contained abundant follicular dendritic cells. Neoplastic cells were small to medium, with irregular cleaved or round nuclei and clear cytoplasm, which was abundant in one case. Lymphoma cells in all cases were CD4+ CD8- CD57- bcl-6, with CD10 coexpression in 2 cases. Clonal rearrangement of the gamma chain of the T-cell receptor gene was demonstrated in each case. These cases expand the differential diagnosis of lymphomas with a follicular growth pattern and suggest that neoplastic T cells may have the capacity to induce or home to follicular structures.
Mots-clé
Antigens, CD4/metabolism, Antigens, CD8/metabolism, Antigens, Neoplasm/metabolism, Clone Cells, DNA, Neoplasm/analysis, DNA-Binding Proteins/metabolism, Dendritic Cells/metabolism, Dendritic Cells/pathology, Diagnosis, Differential, Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, Humans, Immunoenzyme Techniques, Lymph Nodes/metabolism, Lymph Nodes/pathology, Lymphoma, Follicular/genetics, Lymphoma, Follicular/immunology, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/immunology, Male, Middle Aged, Neoplasm Staging, Neprilysin/metabolism, Phenotype, Proto-Oncogene Proteins/metabolism, Proto-Oncogene Proteins c-bcl-6, Transcription Factors/metabolism, Tumor Markers, Biological/metabolism
Pubmed
Création de la notice
28/10/2010 11:39
Dernière modification de la notice
20/08/2019 15:39
Données d'usage