Does reproductive stage impact cardiovascular disease risk factors? Results from a population-based cohort in Lausanne (CoLaus study).

Détails

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Etat: Public
Version: de l'auteur⸱e
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_7E45F2A8C525
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Does reproductive stage impact cardiovascular disease risk factors? Results from a population-based cohort in Lausanne (CoLaus study).
Périodique
Clinical endocrinology
Auteur⸱e⸱s
Raguindin P.F., Cardona I., Muka T., Lambrinoudaki I., Gebhard C., Franco O.H., Marques-Vidal P., Glisic M.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Statut éditorial
Publié
Date de publication
11/2022
Peer-reviewed
Oui
Volume
97
Numéro
5
Pages
568-580
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Menopause has been associated with adverse cardiovascular disease (CVD) risk profile, yet it is unclear whether the changes in CVD risk factors differ by reproductive stage independently of underlying ageing trajectories.
The CoLaus study is a prospective population-based cohort study in Lausanne, Switzerland.
We used data from women at baseline and follow-up (mean: 5.6 ± 0.5 years) from 2003 to 2012 who did not use hormone therapy. We classified women into (i) premenopausal, (ii) menopausal transition, (iii) early (≤5 years) and (iv) late (>5 years) postmenopausal by comparing their menstruation status at baseline and follow-up.
We measured fasting lipids, glucose and cardiovascular inflammatory markers. We used repeated measures (linear mixed models) for longitudinal analysis, using premenopausal women as a reference category. We adjusted analyses for age, medications and lifestyle factors.
We used the data from 1710 women aged 35-75 years. Longitudinal analysis showed that the changes in CVD risk factors were not different in the other three menopausal categories compared to premenopausal women. When age was used as a predictor variable and adjusted for menopause status, most CVD risk factors increased, while interleukin-6 and interleukin-1β decreased with advancing age.
The current study suggests that women have a worsening cardiovascular risk profile as they age, and although menopausal women may have higher levels of cardiovascular risk factors compared to premenopausal women at any given time, the 5-year changes in cardiovascular risk factors may not depend on the reproductive stage.
Mots-clé
Cardiovascular Diseases/epidemiology, Cohort Studies, Female, Glucose, Heart Disease Risk Factors, Hormones, Humans, Interleukin-1beta, Interleukin-6, Lipids, Prospective Studies, cardiovascular diseases, cardiovascular system, female, menopause, reproduction, risk factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/04/2022 7:35
Dernière modification de la notice
19/07/2023 5:57
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