Waddlia chondrophila and Chlamydia trachomatis antibodies in screening infertile women for tubal pathology.

Détails

ID Serval
serval:BIB_7E19BDF55B36
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Waddlia chondrophila and Chlamydia trachomatis antibodies in screening infertile women for tubal pathology.
Périodique
Microbes and Infection
Auteur⸱e⸱s
Verweij S.P., Kebbi-Beghdadi C., Land J.A., Ouburg S., Morré S.A., Greub G.
ISSN
1769-714X (Electronic)
ISSN-L
1286-4579
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
17
Numéro
11-12
Pages
745-748
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Since Waddlia chondrophila is closely related to Chlamydia trachomatis, we hypothesise that W. chondrophila may also be associated with tubal factor infertility (TFI) in women, a major complication of chronic C. trachomatis infection. Five hundred twenty serum samples were tested for anti-Waddlia antibodies by ELISA. Among the 520 investigated women, a total number of 142 (27.3%) has had laparoscopic diagnosis performed, and were either classified TFI positive or negative. Presence of high titres of W. chondrophila antibodies was linked to TFI (p < 0.0001; OR: 7.5; 95% CI: 3.3-17). Moreover, antibody positivity to both W. chondrophila and C. trachomatis-MOMP was strongly associated with TFI (p < 0.0001; OR: 21; 95% CI: 3.8-12E1). This association was much stronger than the statistical association of C. trachomatis-MOMP antibodies only (p < 0.0001; OR: 7.1; 95% CI: 3.7-14), suggesting that co-infection with W. chondrophila and C. trachomatis may lead to more severe reproductive sequelae and immune responses than single infection with either Chlamydiales members.
Pubmed
Web of science
Création de la notice
03/01/2016 17:44
Dernière modification de la notice
20/08/2019 15:39
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