Molecularly defined vaccines for cancer immunotherapy, and protective T cell immunity.

Détails

ID Serval
serval:BIB_7DFE71DD3E23
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Molecularly defined vaccines for cancer immunotherapy, and protective T cell immunity.
Périodique
Seminars in Immunology
Auteur⸱e⸱s
Speiser D.E., Romero P.
ISSN
1096-3618[electronic], 1044-5323[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
22
Numéro
3
Pages
144-154
Langue
anglais
Résumé
Malignant cells are frequently recognized and destroyed by T cells, hence the development of T cell vaccines against established tumors. The challenge is to induce protective type 1 immune responses, with efficient Th1 and CTL activation, and long-term immunological memory. These goals are similar as in many infectious diseases, where successful immune protection is ideally induced with live vaccines. However, large-scale development of live vaccines is prevented by their very limited availability and vector immunogenicity. Synthetic vaccines have multiple advantages. Each of their components (antigens, adjuvants, delivery systems) contributes specifically to induction and maintenance of T cell responses. Here we summarize current experience with vaccines based on proteins and peptide antigens, and discuss approaches for the molecular characterization of clonotypic T cell responses. With carefully designed step-by-step modifications of innovative vaccine formulations, T cell vaccination can be optimized towards the goal of inducing therapeutic immune responses in humans.
Mots-clé
Animals, Antigens, Neoplasm/genetics, Antigens, Neoplasm/immunology, Cancer Vaccines/genetics, Cancer Vaccines/immunology, Clinical Trials as Topic, Humans, Immunity/immunology, Immunotherapy/methods, Mice, Neoplasms/immunology, Neoplasms/therapy, Peptides/genetics, Peptides/immunology, T-Lymphocytes/immunology, Vaccines, Synthetic/genetics, Vaccines, Synthetic/immunology
Pubmed
Web of science
Création de la notice
02/02/2011 10:30
Dernière modification de la notice
20/08/2019 14:39
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