Gene cluster lock after pheromone receptor gene choice

Détails

ID Serval
serval:BIB_7DDF710AD8B4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Gene cluster lock after pheromone receptor gene choice
Périodique
EMBO Journal
Auteur⸱e⸱s
Roppolo  D., Vollery  S., Kan  C. D., Luscher  C., Broillet  M. C., Rodriguez  I.
ISSN
0261-4189 (Print)
Statut éditorial
Publié
Date de publication
07/2007
Volume
26
Numéro
14
Pages
3423-30
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 25
Résumé
In mammals, perception of pheromones is based on the expression in each vomeronasal sensory neuron of a limited set of receptor genes, chosen among a large repertoire. Here, we report an extremely tight control of the monogenic and monoallelic transcription of the V1rb2 receptor gene. Combining genetic and electrophysiological approaches, we show that the transcription of a non-functional V1r allele leads to the coexpression of another, functional V1r gene. The choice of this coexpressed gene surprisingly includes genes located on the cluster homologous to the one from which the mutant allele is transcribed. However, V1r genes located in cis relative to the transcribed mutant allele are excluded from the coexpression choice. Our observations strongly suggest a monogenic regulatory mechanism acting (a) at a general level, via the expression of the V1r receptor itself, and (b) at a more local level, defined by the V1r gene cluster.
Mots-clé
Alleles Animals Chemoreceptors/metabolism Chemotactic Factors/genetics Gene Deletion *Gene Expression Regulation Male Mice Multigene Family/*genetics Neurons, Afferent/cytology/metabolism Receptors, Pheromone/*genetics Vomeronasal Organ/cytology/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 11:01
Dernière modification de la notice
20/08/2019 14:39
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