The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Pereyra, F.; Pereyra, F.; Jia, X.; McLaren, P.J.; Telenti, A.; de Bakker, P.I.; Walker, B.D.; Ripke, S.; Brumme, C.J.; Pulit, S.L.; Carrington, M.; Kadie, C.M.; Carlson, J.M.; Heckerman, D.; Graham, R.R.; Plenge, R.M.; Deeks, S.G.; Gianniny, L.; Crawford, G.; Sullivan, J.; Gonzalez, E.; Davies, L.; Camargo, A.; Moore, J.M.; Beattie, N.; Gupta, S.; Crenshaw, A.; Burtt, N.P.; Guiducci, C.; Gupta, N.; Gao, X.; Qi, Y.; Yuki, Y.; Piechocka-Trocha, A.; Cutrell, E.; Rosenberg, R.; Moss, K.L.; Lemay, P.; O'Leary, J.; Schaefer, T.; Verma, P.; Toth, I.; Block, B.; Baker, B.; Rothchild, A.; Lian, J.; Proudfoot, J.; Alvino, D.M.; Vine, S.; Addo, M.M.; Allen, T.M.; Altfeld, M.; Henn, M.R.; Le Gall, S.; Streeck, H.; Haas, D.W.; Kuritzkes, D.R.; Robbins, G.K.; Shafer, R.W.; Gulick, R.M.; Shikuma, C.M.; Haubrich, R.; Riddler, S.; Sax, P.E.; Daar, E.S.; Ribaudo, H.J.; Agan, B.; Agarwal, S.; Ahern, R.L.; Allen, B.L.; Altidor, S.; Altschuler, E.L.; Ambardar, S.; Anastos, K.; Anderson, B.; Anderson, V.; Andrady, U.; Antoniskis, D.; Bangsberg, D.; Barbaro, D.; Barrie, W.; Bartczak, J.; Barton, S.; Basden, P.; Basgoz, N.; Bazner, S.; Bellos, N.C.; Benson, A.M.; Berger, J.; Bernard, N.F.; Bernard, A.M.; Birch, C.; Bodner, S.J.; Bolan, R.K.; Boudreaux, E.T.; Bradley, M.; Braun, J.F.; Brndjar, J.E.; Brown, S.J.; Brown, K.; Brown, S.T.; Burack, J.; Bush, L.M.; Cafaro, V.; Campbell, O.; Campbell, J.; Carlson, R.H.; Carmichael, J.K.; Casey, K.K.; Cavacuiti, C.; Celestin, G.; Chambers, S.T.; Chez, N.; Chirch, L.M.; Cimoch, P.J.; Cohen, D.; Cohn, L.E.; Conway, B.; Cooper, D.A.; Cornelson, B.; Cox, D.T.; Cristofano, M.V.; Cuchural, G.; Czartoski, J.L.; Dahman, J.M.; Daly, J.S.; Davis, B.T.; Davis, K.; Davod, S.M.; DeJesus, E.; Dietz, C.A.; Dunham, E.; Dunn, M.E.; Ellerin, T.B.; Eron, J.J.; Fangman, J.J.; Farel, C.E.; Ferlazzo, H.; Fidler, S.; Fleenor-Ford, A.; Frankel, R.; Freedberg, K.A.; French, N.K.; Fuchs, J.D.; Fuller, J.D.; Gaberman, J.; Gallant, J.E.; Gandhi, R.T.; Garcia, E.; Garmon, D.; Gathe, J.C.; Gaultier, C.R.; Gebre, W.; Gilman, F.D.; Gilson, I.; Goepfert, P.A.; Gottlieb, M.S.; Goulston, C.; Groger, R.K.; Gurley, T.D.; Haber, S.; Hardwicke, R.; Hardy, W.D.; Harrigan, P.R.; Hawkins, T.N.; Heath, S.; Hecht, F.M.; Henry, W.K.; Hladek, M.; Hoffman, R.P.; Horton, J.M.; Hsu, R.K.; Huhn, G.D.; Hunt, P.; Hupert, M.J.; Illeman, M.L.; Jaeger, H.; Jellinger, R.M.; John, M.; Johnson, J.A.; Johnson, K.L.; Johnson, H.; Johnson, K.; Joly, J.; Jordan, W.C.; Kauffman, C.A.; Khanlou, H.; Killian, R.K.; Kim, A.Y.; Kim, D.D.; Kinder, C.A.; Kirchner, J.T.; Kogelman, L.; Kojic, E.M.; Korthuis, P.T.; Kurisu, W.; Kwon, D.S.; LaMar, M.; Lampiris, H.; Lanzafame, M.; Lederman, M.M.; Lee, D.M.; Lee, J.M.; Lee, M.J.; Lee, E.T.; Lemoine, J.; Levy, J.A.; Llibre, J.M.; Liguori, M.A.; Little, S.J.; Liu, A.Y.; Lopez, A.J.; Loutfy, M.R.; Loy, D.; Mohammed, D.Y.; Man, A.; Mansour, M.K.; Marconi, V.C.; Markowitz, M.; Marques, R.; Martin, J.N.; Martin, H.L.; Mayer, K.H.; McElrath, M.J.; McGhee, T.A.; McGovern, B.H.; McGowan, K.; McIntyre, D.; Mcleod, G.X.; Menezes, P.; Mesa, G.; Metroka, C.E.; Meyer-Olson, D.; Miller, A.O.; Montgomery, K.; Mounzer, K.C.; Nagami, E.H.; Nagin, I.; Nahass, R.G.; Nelson, M.O.; Nielsen, C.; Norene, D.L.; O'Connor, D.H.; Ojikutu, B.O.; Okulicz, J.; Oladehin, O.O.; Oldfield, E.C.; Olender, S.A.; Ostrowski, M.; Owen, W.F.; Pae, E.; Parsonnet, J.; Pavlatos, A.M.; Perlmutter, A.M.; Pierce, M.N.; Pincus, J.M.; Pisani, L.; Price, L.J.; Proia, L.; Prokesch, R.C.; Pujet, H.C.; Ramgopal, M.; Rathod, A.; Rausch, M.; Ravishankar, J.; Rhame, F.S.; Richards, C.S.; Richman, D.D.; Rodes, B.; Rodriguez, M.; Rose, R.C.; Rosenberg, E.S.; Rosenthal, D.; Ross, P.E.; Rubin, D.S.; Rumbaugh, E.; Saenz, L.; Salvaggio, M.R.; Sanchez, W.C.; Sanjana, V.M.; Santiago, S.; Schmidt, W.; Schuitemaker, H.; Sestak, P.M.; Shalit, P.; Shay, W.; Shirvani, V.N.; Silebi, V.I.; Sizemore, J.M.; Skolnik, P.R.; Sokol-Anderson, M.; Sosman, J.M.; Stabile, P.; Stapleton, J.T.; Starrett, S.; Stein, F.; Stellbrink, H.J.; Sterman, F.L.; Stone, V.E.; Stone, D.R.; Tambussi, G.; Taplitz, R.A.; Tedaldi, E.M.; Telenti, A.; Theisen, W.; Torres, R.; Tosiello, L.; Tremblay, C.; Tribble, M.A.; Trinh, P.D.; Tsao, A.; Ueda, P.; Vaccaro, A.; Valadas, E.; Vanig, T.J.; Vecino, I.; Vega, V.M.; Veikley, W.; Wade, B.H.; Walworth, C.; Wanidworanun, C.; Ward, D.J.; Warner, D.A.; Weber, R.D.; Webster, D.; Weis, S.; Wheeler, D.A.; White, D.J.; Wilkins, E.; Winston, A.; Wlodaver, C.G.; van't Wout, A.; Wright, D.P.; Yang, O.O.; Yurdin, D.L.; Zabukovic, B.W.; Zachary, K.C.; Zeeman, B.; Zhao, M.

doi:10.1126/science.1195271

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Détails

Télécharger: BIB_7DB03A4B1733.P001.pdf (1610.82 [Ko])
Etat: Public
Version: de l'auteur⸱e

ID Serval

serval:BIB_7DB03A4B1733

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Périodique

Science (new York, N.y.)

Auteur⸱e⸱s

Pereyra F., Pereyra F., Jia X., McLaren P.J., Telenti A., de Bakker P.I., Walker B.D., Ripke S., Brumme C.J., Pulit S.L., Carrington M., Kadie C.M., Carlson J.M., Heckerman D., Graham R.R., Plenge R.M., Deeks S.G., Gianniny L., Crawford G., Sullivan J., Gonzalez E., Davies L., Camargo A., Moore J.M., Beattie N., Gupta S., Crenshaw A., Burtt N.P., Guiducci C., Gupta N., Gao X., Qi Y., Yuki Y., Piechocka-Trocha A., Cutrell E., Rosenberg R., Moss K.L., Lemay P., O'Leary J., Schaefer T., Verma P., Toth I., Block B., Baker B., Rothchild A., Lian J., Proudfoot J., Alvino D.M., Vine S., Addo M.M., Allen T.M., Altfeld M., Henn M.R., Le Gall S., Streeck H., Haas D.W., Kuritzkes D.R., Robbins G.K., Shafer R.W., Gulick R.M., Shikuma C.M., Haubrich R., Riddler S., Sax P.E., Daar E.S., Ribaudo H.J., Agan B., Agarwal S., Ahern R.L., Allen B.L., Altidor S., Altschuler E.L., Ambardar S., Anastos K., Anderson B., Anderson V., Andrady U., Antoniskis D., Bangsberg D., Barbaro D., Barrie W., Bartczak J., Barton S., Basden P., Basgoz N., Bazner S., Bellos N.C., Benson A.M., Berger J., Bernard N.F., Bernard A.M., Birch C., Bodner S.J., Bolan R.K., Boudreaux E.T., Bradley M., Braun J.F., Brndjar J.E., Brown S.J., Brown K., Brown S.T., Burack J., Bush L.M., Cafaro V., Campbell O., Campbell J., Carlson R.H., Carmichael J.K., Casey K.K., Cavacuiti C., Celestin G., Chambers S.T., Chez N., Chirch L.M., Cimoch P.J., Cohen D., Cohn L.E., Conway B., Cooper D.A., Cornelson B., Cox D.T., Cristofano M.V., Cuchural G., Czartoski J.L., Dahman J.M., Daly J.S., Davis B.T., Davis K., Davod S.M., DeJesus E., Dietz C.A., Dunham E., Dunn M.E., Ellerin T.B., Eron J.J., Fangman J.J., Farel C.E., Ferlazzo H., Fidler S., Fleenor-Ford A., Frankel R., Freedberg K.A., French N.K., Fuchs J.D., Fuller J.D., Gaberman J., Gallant J.E., Gandhi R.T., Garcia E., Garmon D., Gathe J.C., Gaultier C.R., Gebre W., Gilman F.D., Gilson I., Goepfert P.A., Gottlieb M.S., Goulston C., Groger R.K., Gurley T.D., Haber S., Hardwicke R., Hardy W.D., Harrigan P.R., Hawkins T.N., Heath S., Hecht F.M., Henry W.K., Hladek M., Hoffman R.P., Horton J.M., Hsu R.K., Huhn G.D., Hunt P., Hupert M.J., Illeman M.L., Jaeger H., Jellinger R.M., John M., Johnson J.A., Johnson K.L., Johnson H., Johnson K., Joly J., Jordan W.C., Kauffman C.A., Khanlou H., Killian R.K., Kim A.Y., Kim D.D., Kinder C.A., Kirchner J.T., Kogelman L., Kojic E.M., Korthuis P.T., Kurisu W., Kwon D.S., LaMar M., Lampiris H., Lanzafame M., Lederman M.M., Lee D.M., Lee J.M., Lee M.J., Lee E.T., Lemoine J., Levy J.A., Llibre J.M., Liguori M.A., Little S.J., Liu A.Y., Lopez A.J., Loutfy M.R., Loy D., Mohammed D.Y., Man A., Mansour M.K., Marconi V.C., Markowitz M., Marques R., Martin J.N., Martin H.L., Mayer K.H., McElrath M.J., McGhee T.A., McGovern B.H., McGowan K., McIntyre D., Mcleod G.X., Menezes P., Mesa G., Metroka C.E., Meyer-Olson D., Miller A.O., Montgomery K., Mounzer K.C., Nagami E.H., Nagin I., Nahass R.G., Nelson M.O., Nielsen C., Norene D.L., O'Connor D.H., Ojikutu B.O., Okulicz J., Oladehin O.O., Oldfield E.C., Olender S.A., Ostrowski M., Owen W.F., Pae E., Parsonnet J., Pavlatos A.M., Perlmutter A.M., Pierce M.N., Pincus J.M., Pisani L., Price L.J., Proia L., Prokesch R.C., Pujet H.C., Ramgopal M., Rathod A., Rausch M., Ravishankar J., Rhame F.S., Richards C.S., Richman D.D., Rodes B., Rodriguez M., Rose R.C., Rosenberg E.S., Rosenthal D., Ross P.E., Rubin D.S., Rumbaugh E., Saenz L., Salvaggio M.R., Sanchez W.C., Sanjana V.M., Santiago S., Schmidt W., Schuitemaker H., Sestak P.M., Shalit P., Shay W., Shirvani V.N., Silebi V.I., Sizemore J.M., Skolnik P.R., Sokol-Anderson M., Sosman J.M., Stabile P., Stapleton J.T., Starrett S., Stein F., Stellbrink H.J., Sterman F.L., Stone V.E., Stone D.R., Tambussi G., Taplitz R.A., Tedaldi E.M., Telenti A., Theisen W., Torres R., Tosiello L., Tremblay C., Tribble M.A., Trinh P.D., Tsao A., Ueda P., Vaccaro A., Valadas E., Vanig T.J., Vecino I., Vega V.M., Veikley W., Wade B.H., Walworth C., Wanidworanun C., Ward D.J., Warner D.A., Weber R.D., Webster D., Weis S., Wheeler D.A., White D.J., Wilkins E., Winston A., Wlodaver C.G., van't Wout A., Wright D.P., Yang O.O., Yurdin D.L., Zabukovic B.W., Zachary K.C., Zeeman B., Zhao M.

Collaborateur⸱rice⸱s

International HIV Controllers Study

ISSN

1095-9203 (Electronic)

ISSN-L

0036-8075

Statut éditorial

Publié

Date de publication

2010

Peer-reviewed

Oui

Volume

330

Numéro

6010

Pages

1551-1557

Langue

anglais

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish

Résumé

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.

Mots-clé

African Americans/genetics, Alleles, Amino Acids/physiology, Antigen Presentation, CD8-Positive T-Lymphocytes/immunology, Cohort Studies, Disease Progression, European Continental Ancestry Group/genetics, Genes, MHC Class I, Genome-Wide Association Study, HIV Antigens/immunology, HIV Infections/ethnology, HIV Infections/genetics, HIV Long-Term Survivors, HIV-1/immunology, HLA-A Antigens/chemistry, HLA-A Antigens/genetics, HLA-B Antigens/chemistry, HLA-B Antigens/genetics, HLA-C Antigens/chemistry, HLA-C Antigens/genetics, Haplotypes, Hispanic Americans/genetics, Humans, Immunity, Innate, Logistic Models, Models, Molecular, Polymorphism, Single Nucleotide, Protein Conformation, Viral Load

URN

urn:nbn:ch:serval-BIB_7DB03A4B17331

OAI-PMH

oai:serval.unil.ch:BIB_7DB03A4B1733

DOI

10.1126/science.1195271

Pubmed

21051598

Web of science

000285153500069

Open Access

Oui