Can the trabecular bone score (TBS) be considered as a major clinical risk factor (CRF) of osteoporotic fractures? A meta-like analysis
Détails
ID Serval
serval:BIB_7D9CF48DCE87
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Can the trabecular bone score (TBS) be considered as a major clinical risk factor (CRF) of osteoporotic fractures? A meta-like analysis
Titre de la conférence
ECTS 2012, 39th Annual Congress of the European Calcified Tissue Society
Adresse
Stockholm, Sweden, May 19-23, 2012
ISBN
8756-3282
Statut éditorial
Publié
Date de publication
2012
Volume
1
Série
Bone
Pages
S151
Langue
anglais
Notes
Meeting Abstract
Résumé
Abstract: To have an added value over BMD, a CRF of osteoporotic fracture must be
predictable of the fracture, independent of BMD, reversible and quantifiable. Many major
recognized CRF exist.Out of these factorsmany of themare indirect factor of bone quality. TBS
predicts fracture independently of BMD as demonstrated from previous studies. The aim of
the study is to verify if TBS can be considered as a major CRF of osteoporotic fracture.
Existing validated datasets of Caucasian women were analyzed. These datasets
stem from different studies performed by the authors of this report or provided to our
group. However, the level of evidence of these studies will vary. Thus, the different
datasets were weighted differently according to their design.
This meta-like analysis involves more than 32000 women (≥50 years) with 2000
osteoporotic fractures from two prospective studies (OFELY&MANITOBA) and 7 crosssectional
studies. Weighted relative risk (RR) for TBS was expressed for each decrease
of one standard deviation as well as per tertile difference (TBS=1.300 and 1.200) and
compared with those obtained for the major CRF included in FRAX®.
Overall TBS RR obtained (adjusted for age) was 1.79 [95%CI-1.37-2.37]. For all women
combined, RR for fracture for the lowest comparedwith themiddle TBS tertilewas 1.55[1.46-
1.68] and for the lowest compared with the highest TBS tertile was 2.8[2.70-3.00].
TBS is comparable to most of the major CRF (Fig 1) and thus could be used as one
of them. Further studies have to be conducted to confirm these first findings.
predictable of the fracture, independent of BMD, reversible and quantifiable. Many major
recognized CRF exist.Out of these factorsmany of themare indirect factor of bone quality. TBS
predicts fracture independently of BMD as demonstrated from previous studies. The aim of
the study is to verify if TBS can be considered as a major CRF of osteoporotic fracture.
Existing validated datasets of Caucasian women were analyzed. These datasets
stem from different studies performed by the authors of this report or provided to our
group. However, the level of evidence of these studies will vary. Thus, the different
datasets were weighted differently according to their design.
This meta-like analysis involves more than 32000 women (≥50 years) with 2000
osteoporotic fractures from two prospective studies (OFELY&MANITOBA) and 7 crosssectional
studies. Weighted relative risk (RR) for TBS was expressed for each decrease
of one standard deviation as well as per tertile difference (TBS=1.300 and 1.200) and
compared with those obtained for the major CRF included in FRAX®.
Overall TBS RR obtained (adjusted for age) was 1.79 [95%CI-1.37-2.37]. For all women
combined, RR for fracture for the lowest comparedwith themiddle TBS tertilewas 1.55[1.46-
1.68] and for the lowest compared with the highest TBS tertile was 2.8[2.70-3.00].
TBS is comparable to most of the major CRF (Fig 1) and thus could be used as one
of them. Further studies have to be conducted to confirm these first findings.
Web of science
Création de la notice
24/01/2013 11:16
Dernière modification de la notice
20/08/2019 14:38
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