Photodynamic therapy for focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy.

Détails

ID Serval
serval:BIB_7D7F831D706A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Photodynamic therapy for focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy.
Périodique
Ophthalmology
Auteur⸱e⸱s
Ober M.D., Yannuzzi L.A., Do D.V., Spaide R.F., Bressler N.M., Jampol L.M., Angelilli A., Eandi C.M., Lyon A.T.
ISSN
1549-4713 (Electronic)
ISSN-L
0161-6420
Statut éditorial
Publié
Date de publication
12/2005
Peer-reviewed
Oui
Volume
112
Numéro
12
Pages
2088-2094
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To report the use of photodynamic therapy with verteporfin as a treatment for patients with focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy (CSC).
Noncomparative, nonrandomized, retrospective interventional case series.
Nine eyes of 9 symptomatic patients with acute focal retinal pigment epithelial leaks secondary to CSC, confirmed with fluorescein angiography, evaluated at 1 of 3 referral retina practices.
Patients were treated with photodynamic therapy using verteporfin. Best-corrected visual acuity (VA) was recorded at presentation and follow-up visits.
Resolution of neurosensory detachment, status of fluorescein leakage, and VA.
Neurosensory detachment and fluorescein leakage resolved in all patients within 1 month. Visual acuity improved from 1 to 6 lines in 7 eyes and remained unchanged in 2. At 6 months, there was a statistically significant improvement in mean VA (P = 0.012, Wilcoxon signed ranks test), and mean VA improved from 20/80 to 20/40. No patient lost vision or suffered any treatment-related complications.
The treatment of acute CSC with photodynamic therapy may result in prompt resolution of neurosensory detachment and fluorescein leakage, which can be associated with rapidly improved vision. Although this case series is limited in follow-up and number of patients, the encouraging results and lack of visually significant complications suggest that further investigation is warranted.
Mots-clé
Adult, Capillary Permeability/drug effects, Choroid Diseases/complications, Choroid Diseases/diagnosis, Choroid Diseases/drug therapy, Exudates and Transudates, Female, Fluorescein Angiography, Humans, Male, Middle Aged, Photochemotherapy, Photosensitizing Agents/therapeutic use, Pigment Epithelium of Eye/blood supply, Pigment Epithelium of Eye/pathology, Porphyrins/therapeutic use, Retinal Detachment/complications, Retinal Detachment/diagnosis, Retinal Detachment/drug therapy, Retinal Diseases/complications, Retinal Diseases/diagnosis, Retinal Diseases/drug therapy, Retrospective Studies, Serum, Verteporfin, Visual Acuity
Pubmed
Web of science
Création de la notice
11/03/2021 19:50
Dernière modification de la notice
26/03/2021 7:35
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