Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin

Détails

ID Serval
serval:BIB_7D4A3F5937BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin
Périodique
Journal of Pediatric Endocrinology and Metabolism
Auteur(s)
Kanaka-Gantenbein  C., Catzeflis  C., Keller  U., Fathi  M., Theintz  G. E., Sizonenko  P. C.
ISSN
0334-018X (Print)
Statut éditorial
Publié
Date de publication
02/1999
Volume
12
Numéro
1
Pages
39-46
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Jan-Feb
Résumé
After transfer of diabetic patients from porcine to human insulin, many reports emerged supporting an increased hypoglycemia unawareness. Several studies were then undertaken in both diabetic and healthy adults to investigate counterregulatory hormone responses to both porcine and human insulin-induced hypoglycemia as a possible underlying cause for this different hypoglycemia awareness. Most studies demonstrated similar neuroendocrine responses to both insulin species in adults. However, no such studies have ever been performed in healthy children. We undertook a double-blinded study of counterregulatory hormone responses to both porcine and human insulin-induced hypoglycemia in 17 short normal children randomly assigned to two groups, one receiving human and the other porcine insulin. We found similar responses of growth hormone, cortisol, epinephrine, norepinephrine and dopamine to both porcine insulin- and human insulin- induced hypoglycemia. Interestingly, we observed a significantly higher glucagon secretion when hypoglycemia was induced by human insulin. In conclusion, human insulin induces a higher glucagon secretion in healthy children than porcine insulin. Evidently, this observation cannot be extrapolated to diabetic patients. This study, however, further underlines the importance of performing investigations in children, since results found in adults differ from those observed in children.
Mots-clé
Adolescent Animals Blood Glucose/metabolism Catecholamines/blood Child Double-Blind Method Female Glucagon/blood/*metabolism Growth Disorders/*blood Growth Hormone/blood Humans Hydrocortisone/blood Hypoglycemia/*blood/chemically induced Insulin/*pharmacology Male Species Specificity Swine
Pubmed
Web of science
Création de la notice
25/01/2008 10:30
Dernière modification de la notice
20/08/2019 14:38
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