Insulin sensitivity and exogenous insulin clearance in Graves' disease. Measurement by the glucose clamp technique and continuous indirect calorimetry

Détails

ID Serval
serval:BIB_7D464730D349
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Insulin sensitivity and exogenous insulin clearance in Graves' disease. Measurement by the glucose clamp technique and continuous indirect calorimetry
Périodique
Diabetes
Auteur⸱e⸱s
Randin  J. P., Tappy  L., Scazziga  B., Jequier  E., Felber  J. P.
ISSN
0012-1797 (Print)
Statut éditorial
Publié
Date de publication
02/1986
Volume
35
Numéro
2
Pages
178-81
Notes
Journal Article --- Old month value: Feb
Résumé
Insulin sensitivity was measured in a group of seven thyrotoxic patients and in a group of seven normal subjects by means of the glucose clamp technique. Infusion of insulin at a rate of 0.80 +/- 0.05 mU/kg X min in the hyperthyroid patients and of 0.55 +/- 0.04 mU/kg X min in the control group was performed to obtain a steady-state plasma insulin concentration of approximately 50 microU/ml. Substrate oxidation rates were measured in the postabsorptive state and during the 2 h of the clamp by means of continuous indirect calorimetry. In the postabsorptive state, hyperthyroid patients presented a preferential oxidation of lipids. During the period 60-120 min of the clamp, mean plasma glucose (92 +/- 2 versus 93 +/- 2 mg/dl), insulin (50 +/- 5 versus 58 +/- 3 microU/ml), and total glucose metabolism (5.8 +/- 0.7 versus 6.1 +/- 0.3 mg/kg X min) were similar in the hyperthyroid patients and the control subjects. The rate of glucose oxidation was higher in hyperthyroid patients than in control subjects (4.3 +/- 0.5 versus 2.2 +/- 0.2 mg/kg X min, P less than 0.001), while that of lipid oxidation was similar in both groups (0.6 +/- 0.2 versus control 0.7 +/- 0.1 mg/kg X min). The calculated metabolic clearance rate of insulin was markedly higher in the hyperthyroid patients (1144 +/- 132 ml/min) than in the normal subjects (812 +/- 56 ml/min, P less than 0.025). It is concluded that insulin sensitivity is not altered in the thyrotoxic state. The major route of insulin-stimulated glucose disposal in the hyperthyroid patients appears to be glucose oxidation.
Mots-clé
Adult Blood Glucose/analysis *Calorimetry *Calorimetry, Indirect Fatty Acids, Nonesterified/blood Female Graves Disease/*metabolism/physiopathology Humans Hyperinsulinism/metabolism Hyperthyroidism/metabolism/physiopathology Insulin/blood/*metabolism Male Middle Aged
Pubmed
Web of science
Création de la notice
24/01/2008 13:37
Dernière modification de la notice
20/08/2019 14:38
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