Transformation of a microprolactinoma into a mixed growth hormone and prolactin-secreting pituitary adenoma.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_7D2FAB69D989
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Transformation of a microprolactinoma into a mixed growth hormone and prolactin-secreting pituitary adenoma.
Périodique
Frontiers in Endocrinology
Auteur(s)
Dessimoz C., Browaeys P., Maeder P., Lhermitte B., Pitteloud N., Momjian S., Pralong F.P.
ISSN
1664-2392 (Electronic)
ISSN-L
1664-2392
Statut éditorial
Publié
Date de publication
2011
Volume
2
Numéro
116
Pages
1-5
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Combined prolactin (PRL) and growth hormone (GH) secretion by a single pituitary tumor can occur in approximately 5% of cases. However, in all previously reported patients, combined secretion of both hormones was present at the time of diagnosis. Here we describe a patient initially diagnosed with a pure prolactin-secreting microadenoma, who experienced the progressive apparition of symptomatic autonomous GH secretion while on intermittent long term dopamine agonist therapy. She was operated on, and immunohistochemical analysis of tumor tissue confirmed the diagnosis of pituitary adenoma with uniform co-staining of all cells for both GH and PRL. This patient represents the first documented occurrence of asynchronous development of combined GH and PRL secretion in a pituitary adenoma. Although pathogenic mechanisms implicated remain largely speculative, it emphasizes the need for long term hormonal follow up of patients harboring prolactinomas.
Pubmed
Open Access
Oui
Création de la notice
12/02/2013 15:03
Dernière modification de la notice
20/08/2019 15:38
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