Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R<sub>1</sub>, R<sub>2</sub><sup>*</sup> and magnetic susceptibility.

Détails

ID Serval
serval:BIB_7D2DF31B451E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Studying cyto and myeloarchitecture of the human cortex at ultra-high field with quantitative imaging: R<sub>1</sub>, R<sub>2</sub><sup>*</sup> and magnetic susceptibility.
Périodique
NeuroImage
Auteur⸱e⸱s
Marques J.P., Khabipova D., Gruetter R.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
15/02/2017
Peer-reviewed
Oui
Volume
147
Pages
152-163
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
In this manuscript, the use of quantitative imaging at ultra-high field is evaluated as a mean to study cyto and myelo-architecture of the cortex. The quantitative contrasts used are the longitudinal relaxation rate (R <sub>1</sub> ), apparent transverse relaxation rate (R <sub>2 <sup>*</sup></sub> ) and quantitative susceptibility mapping (QSM). The quantitative contrasts were computed using high resolution in-vivo (0.65mm isotropic) brain data acquired at 7T. The performance of the different quantitative approaches was evaluated by visualizing the contrast between known highly myelinated primary sensory cortex regions and the neighbouring cortex. The transition from the inner layers to the outer layers (from white matter to the pial surface) of the human cortex, which is known to have varying cyto- and myelo architecture, was evaluated. The across cortex and through depth behaviour observed for the different quantitative maps was in good agreement between the different subjects, clearly allowing the differentiation between different Brodmann regions, suggesting these features could be used for individual cortical brain parcellation. While both R <sub>1</sub> and R <sub>2</sub> <sup>*</sup> maps decrease monotonically from the white matter to the pial surface due to the decrease of myelin and iron between these regions, magnetic susceptibility maps have a more complex behaviour reflecting its opposing sensitivity to myelin and iron concentration.
Mots-clé
Adult, Algorithms, Brain Mapping, Cerebral Cortex/anatomy & histology, Cerebral Cortex/cytology, Cerebral Cortex/ultrastructure, Electromagnetic Fields, Female, Healthy Volunteers, Humans, Iron/metabolism, Magnetic Resonance Imaging, Magnetics, Male, Myelin Sheath/ultrastructure, Somatosensory Cortex/anatomy & histology, Somatosensory Cortex/cytology, Young Adult
Pubmed
Web of science
Création de la notice
22/12/2016 11:43
Dernière modification de la notice
20/08/2019 14:38
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