Accuracy of clinical diagnosis of behavioural variant frontotemporal dementia: a protocol for a systematic review and meta-analysis.

Détails

ID Serval
serval:BIB_7D277F0BE2F6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Accuracy of clinical diagnosis of behavioural variant frontotemporal dementia: a protocol for a systematic review and meta-analysis.
Périodique
BMJ open
Auteur⸱e⸱s
Urso D., Giannoni-Luza S., Mondello S., Logroscino G.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Statut éditorial
Publié
Date de publication
08/07/2024
Peer-reviewed
Oui
Volume
14
Numéro
7
Pages
e081935
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Behavioural variant frontotemporal dementia (bvFTD) characterisation has evolved, but diagnosis remains challenging, relying on clinical diagnostic criteria that have undergone revisions over time. In this systematic review, our aims are to evaluate the accuracy of clinical diagnostic criteria for bvFTD by comparing them against pathological diagnoses and determine potential improvement in performance over the years.
This systematic review protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 guidelines and is registered on PROSPERO. We will search four databases (MEDLINE-PubMed, Web of Science, Embase and LILACS) using tailored search terms on May 1st 2024. Inclusion criteria encompass peer-reviewed articles reporting diagnostic parameters or raw data regarding bvFTD clinical diagnosis based on well-defined criteria. Screening and selection of relevant articles will be independently performed by two reviewers using the Covidence systematic review manager. Discrepancies will be resolved by a third researcher. Pathologic and genetic diagnosis will be the main gold standard, but we will also consider refined diagnoses after a follow-up period. Data will be collected on study design, baseline demographics and sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy. Study quality will be assessed with Quality Assessment of Diagnostic Accuracy Studies-2. If possible, we will conduct a meta-analysis using bivariate random-effect models. Subgroup analyses will consider study settings, gold standards, disease stages and bias.
Ethics approval will not be needed because the data used in this systematic review will be extracted from published studies. Findings will be disseminated through peer-reviewed publications and presentations at relevant scientific conferences, potentially enhancing our understanding of bvFTD clinical diagnosis reliability and guiding future criteria refinements.
CRD42023389063.
Mots-clé
Humans, Systematic Reviews as Topic, Frontotemporal Dementia/diagnosis, Meta-Analysis as Topic, Research Design, Dementia, EPIDEMIOLOGY, Meta-Analysis, Systematic Review
Pubmed
Open Access
Oui
Création de la notice
12/07/2024 11:55
Dernière modification de la notice
13/07/2024 6:09
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