Allergo-immunologie. 1. Nouveautés dans le traitement des crises aiguës d'angioedème héréditaire [Allergy-immunology. New therapies for acute attacks in hereditary angioedema].

Détails

ID Serval
serval:BIB_7D0E95F1F1E0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Allergo-immunologie. 1. Nouveautés dans le traitement des crises aiguës d'angioedème héréditaire [Allergy-immunology. New therapies for acute attacks in hereditary angioedema].
Périodique
Revue Médicale Suisse
Auteur⸱e⸱s
Leimgruber A.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2011
Volume
7
Numéro
278
Pages
103-105
Langue
français
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
Résumé
Hereditary angioedema is a disease which develops as a result of a deficiency or dysfonction of C1-inhibitor, a key regulator of the complement, coagulation and contact cascades, resulting among others in excessive release of bradykinin. This disease mortality rate is high in absence of immediate and effective treatment, in particular in presence of acute attacks of the upper respiratory tract (laryngeal edema). Until now only administration of a purified C1-inhibitor extract was effective against these symptoms. This paper aims to synthesise essentials knowledge concerning news drugs, in particular icatibant, a selective bradykinin B2- receptor antagonist whose use should be widened to the treatment of angioedema with ACE-inhibitors intolerance.
Mots-clé
Adrenergic beta-Antagonists/therapeutic use, Angioedemas, Hereditary/drug therapy, Bradykinin/analogs & derivatives, Bradykinin/therapeutic use, Complement C1 Inhibitor Protein/therapeutic use, Complement Inactivating Agents/therapeutic use, Humans
Pubmed
Création de la notice
08/11/2011 16:42
Dernière modification de la notice
20/08/2019 14:38
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