Metabolic studies in primary tubular hypomagnesaemia-hypokalaemia

Détails

ID Serval
serval:BIB_7C89FA033A9F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Metabolic studies in primary tubular hypomagnesaemia-hypokalaemia
Périodique
Magnesium Research
Auteur(s)
Bianchetti  M. G., Girardin  E., Benador-Milsztajn  N., Sizonenko  P. C., Paunier  L.
ISSN
0953-1424
Statut éditorial
Publié
Date de publication
07/1988
Peer-reviewed
Oui
Volume
1
Numéro
1-2
Pages
79-83
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
13 1/2 year old boy with short stature and pubertal delay had infrequent episodes of tetany. Biochemical determinations demonstrated low plasma and high urinary magnesium and potassium levels, hypocalciuria, slightly increased plasma bicarbonate, slightly reduced fractional distal reabsorption of chloride and sodium, high plasma renin activity and high urinary excretion of prostaglandins (E2, F2 alpha). The other parameters of renal functions were normal. Endocrine evaluation of short stature and pubertal delay was normal. Intracellular magnesium and potassium levels in lymphocytes and erythrocytes were within normal limits. Cyclooxygenase blockade with Indomethacin 2.5 mg/kg daily during 4 weeks normalized urinary excretion of prostaglandins and corrected in part low plasma and high urinary potassium levels, but had no effect on magnesium, calcium, sodium and chloride handling. These data raise the possibility that tubular hypomagnesaemia-hypokalaemia could be solely explained by a low renal threshold for magnesium.
Mots-clé
Adolescent Erythrocytes/metabolism Humans Hypokalemia/blood/*physiopathology/urine Indomethacin/therapeutic use Kidney Tubules/metabolism/*physiopathology Lymphocytes/metabolism Magnesium/*blood/urine Male Metal Metabolism, Inborn Errors/blood/*physiopathology/urine Potassium/*blood/urine Prostaglandins/urine Puberty, Delayed/blood/*physiopathology/urine
Pubmed
Création de la notice
15/01/2008 15:27
Dernière modification de la notice
20/08/2019 15:38
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