CCTTT-repeat polymorphism of the inducible nitric oxide synthase is not associated with HIV pathogenesis

Détails

ID Serval
serval:BIB_7C653E859975
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
CCTTT-repeat polymorphism of the inducible nitric oxide synthase is not associated with HIV pathogenesis
Périodique
Clinical and Experimental Immunology
Auteur⸱e⸱s
Hersberger  M., Bonhoeffer  S., Rampini  S. K., Opravil  M., Marti-Jaun  J., Telenti  A., Hanseler  E., Ledergerber  B., Speck  R. F.
ISSN
0009-9104 (Print)
Statut éditorial
Publié
Date de publication
09/2004
Volume
137
Numéro
3
Pages
566-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
Nitric oxide (NO) produced by the inducible form of nitric oxide synthase (iNOS) has bactericidal and virocidal effects. Although NO synthesis and iNOS expression in macrophages affect several aspects of human immunodeficiency virus (HIV) type-1 pathogenesis, their role in HIV disease remains largely unknown. In humans, the expression of iNOS is influenced by a functional CCTTT-repeat polymorphism in the promoter region of the gene. We investigated the association of this polymorphism with HIV pathogenesis in naive HIV-infected patients before the initiation of antiretroviral therapy. The allele frequencies of the iNOS CCTTT-repeat polymorphism were assessed by PCR in 857 patients from the Swiss HIV Cohort Study, including rapid progressors and long-term nonprogressors, and in 240 healthy volunteers. In HIV-infected patients, the initial viral load and the decline in total CD4 cells was calculated to estimate disease progression. Allele frequencies of the iNOS CCTTT-repeat polymorphism were similar between the HIV-infected and noninfected blood donors. In treatment-naive HIV-positive patients, there was no association of the iNOS polymorphism with viral load or with the course of CD4 cells. Regulation of iNOS expression by the functional CCTTT-polymorphism does not modify HIV pathogenesis.
Mots-clé
Adult CD4-Positive T-Lymphocytes/immunology Case-Control Studies Disease Progression Gene Frequency HIV Infections/*etiology/immunology/metabolism HIV-1/*pathogenicity Humans Linear Models Nitric Oxide Synthase/*genetics Nitric Oxide Synthase Type II Polymerase Chain Reaction/methods *Polymorphism, Genetic *Promoter Regions (Genetics) Viral Load
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 14:45
Dernière modification de la notice
20/08/2019 14:38
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