Corticosteroids and the retina: a role for the mineralocorticoid receptor.

Détails

ID Serval
serval:BIB_7C127939A938
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Corticosteroids and the retina: a role for the mineralocorticoid receptor.
Périodique
Current Opinion In Neurology
Auteur⸱e⸱s
Behar-Cohen F., Zhao M.
ISSN
1473-6551 (Electronic)
ISSN-L
1350-7540
Statut éditorial
Publié
Date de publication
02/2016
Peer-reviewed
Oui
Volume
29
Numéro
1
Pages
49-54
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
PURPOSE OF REVIEW: Long-lasting devices releasing steroids have been approved recently for macular edema of various origins. Identification of the retina as a novel mineralo-sensitive tissue also raises new therapeutic options.
RECENT FINDINGS: Recently, the over activation of the mineralocorticoid receptor (MR) pathway has been shown to cause fluid accumulation in the retina, choroidal vasodilation, and to promote retinal neovascularization in hypoxic conditions. These findings indicate that MR antagonists could have beneficial effects in the treatment of retinal diseases. Central serous chorioretinopathy is a retinal disease associated with choroidal vasodilation and subretinal fluid that affects mostly men with type A personality and occurrence has been associated with steroid intake. In several independent studies, MR antagonists have shown beneficial effects, significantly reducing subretinal fluid in eyes of chronic central serous chorioretinopathy patients.
SUMMARY: The role of MR in retinal disorder is emerging and the potential association with psychological traits is considered. The place of MR antagonists for retinal diseases treatment is discussed.
Mots-clé
Adrenal Cortex Hormones/therapeutic use, Central Serous Chorioretinopathy, Humans, Macular Edema/drug therapy, Mineralocorticoid Receptor Antagonists/therapeutic use, Receptors, Mineralocorticoid/metabolism, Retina/drug effects
Pubmed
Web of science
Création de la notice
28/01/2016 12:28
Dernière modification de la notice
20/08/2019 15:37
Données d'usage