The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects.

Détails

Ressource 1Télécharger: 5_25917368_Postprint.pdf (794.58 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_7C0FB3FC8AAF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects.
Périodique
Molecular psychiatry
Auteur(s)
Peyrot W.J., Lee S.H., Milaneschi Y., Abdellaoui A., Byrne E.M., Esko T., de Geus E.J., Hemani G., Hottenga J.J., Kloiber S., Levinson D.F., Lucae S., Martin N.G., Medland S.E., Metspalu A., Milani L., Noethen M.M., Potash J.B., Rietschel M., Rietveld C.A., Ripke S., Shi J., Willemsen G., Zhu Z., Boomsma D.I., Wray N.R., Penninx B.W.
Collaborateur(s)
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium (Corporate Collaborator), Social Science Genetic Association Consortium Corporate Collaborator, Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium Corporate Collaborator, Social Science Genetic Association Consortium Corporate Collaborator
Contributeur(s)
Lewis C.M., Hamilton S.P., Weissman M.M., Breen G., Blackwood D.H., Cichon S., Heath A.C., Holsboer F., Madden P.A., McGuffin P., Muglia P., Pergadia M.L., Lin D., Müller-Myhsok B., Steinberg S., Grabe H.J., Lichtenstein P., Magnusson P., Perlis R.H., Preisig M., Smoller J.W., Stefansson K., Uher R., Kutalik Z., Tansey K.E., Teumer A., Viktorin A., Barnes M.R., Bettecken T., Binder E.B., Breuer R., Castro V.M., Churchill S.E., Coryell W.H., Craddock N., Craig I.W., Czamara D., Degenhardt F., Farmer A.E., Fava M., Frank J., Gainer V.S., Gallagher P.J., Gordon S.D., Goryachev S., Gross M., Guipponi M., Henders A.K., Herms S., Hickie I.B., Hoefels S., Hoogendijk W., Iosifescu D.V., Ising M., Jones I., Jones L., Jung-Ying T., Knowles J.A., Kohane I.S., Kohli M.A., Korszun A., Landen M., Lawson W.B., Lewis G., Macintyre D., Maier W., Mattheisen M., McGrath P.J., McIntosh A., McLean A., Middeldorp C.M., Middleton L., Montgomery G.M., Murphy S.N., Nauck M., Nolen W.A., Nyholt D.R., O'Donovan M., Oskarsson H., Pedersen N., Scheftner W.A., Schulz A., Schulze T.G., Shyn S.I., Sigurdsson E., Slager S.L., Smit J.H., Stefansson H., Steffens M., Thorgeirsson T., Tozzi F., Treutlein J., Uhr M., van den Oord E.J., Van Grootheest G., Völzke H., Weilburg J.B., Willemsen G., Zitman F.G., Neale B., Daly M., Sullivan P.F., Agrawal A., Albrecht E., Alizadeh B.Z., Allik J., Amin N., Attia J.R., Bandinelli S., Barnard J., Bastardot F., Baumeister S.E., Beauchamp J., Benjamin D.J., Benke K.S., Bennett D.A., Berger K., Bielak L.F., Bierut L.J., Boatman J.A., Boyle P.A., Bültmann U., Campbell H., Cesarini D., Chabris C.F., Cherkas L., Chung M.K., Conley D., Cucca F., Davey-Smith G., Davies G., de Andrade M., De Jager P.L., de Leeuw C., De Neve J.E., Deary I.J., Dedoussis G.V., Deloukas P., Derringer J., Dimitriou M., Eiriksdottir G., Eklund N., Elderson M.F., Eriksson J.G., Evans D.S., Evans D.M., Faul J.D., Fehrmann R., Ferrucci L., Fischer K., Franke L., Garcia M.E., Gieger C., Gjessing H.K., Groenen P.J., Grönberg H., Gudnason V., Hägg S., Hall P., Harris J.R., Harris J.M., Harris T.B., Hastie N.D., Hayward C., Heath A.C., Hernandez D.G., Hoffmann W., Hofman A., Hofman A., Holle R., Holliday E.G., Holzapfel C., Iacono W.G., Ibrahim-Verbaas C.A., Illig T., Ingelsson E., Jacobsson B., Järvelin M.R., Jhun M.A., Johannesson M., Joshi P.K., Jugessur A., Kaakinen M., Kähönen M., Kanoni S., Kaprio J., Kardia S.L., Karjalainen J., Kirkpatrick R.M., Koellinger P.D., Kolcic I., Kowgier M., Kristiansson K., Krueger R.F., Kutalik Z., Lahti J., Laibson D., Latvala A., Launer L.J., Lawlor D.A., Lethimäki T., Li J., Lichtenstein P., Lichtner P.K., Liewald D.C., Lin P., Lind P.A., Liu Y., Lohman K., Loitfelder M., Madden P.A., Magnusson P.K., Mäkinen T.E., Vidal P.M., Martin N.W., Masala M., McGue M., McMahon G., Meirelles O., Meyer M.N., Mielck A., Milani L., Miller M.B., Montgomery G.W., Mukherjee S., Myhre R., Nuotio M.L., Nyholt D.R., Oldmeadow C.J., Oostra B.A., Palmer L.J., Palotie A., Perola M., Petrovic K.E., Peyser P.A., Polašek O., Posthuma D., Preisig M., Quaye L., Räikkönen K., Raitakari O.T., Realo A., Reinmaa E., Rice J.P., Ring S.M., Ripatti S., Rivadeneira F., Rizzi T.S., Rudan I., Rustichini A., Salomaa V., Sarin A.P., Schlessinger D., Schmidt H., Schmidt R., Scott R.J., Shakhbazov K., Smith A.V., Smith J.A., Snieder H., Pourcain B.S., Starr J.M., Sul J.H., Surakka I., Svento R., Tanaka T., Terracciano A., Teumer A., Thurik A.R., Tiemeier H., Timpson N.J., Uitterlinden A.G., van der Loos M.J., van Duijn C.M., van Rooij F.J., Van Wagoner D.R., Vartiainen E., Viikari J., Visscher P.M., Vitart V., Vollenweider P.K., Völzke H., Vonk J.M., Waeber G., Weir D.R., Wellmann J., Westra H.J., Wichmann H.E., Widen E., Wilson J.F., Wright A.F., Yang J., Yu L., Zhao W.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Statut éditorial
Publié
Date de publication
06/2015
Peer-reviewed
Oui
Volume
20
Numéro
6
Pages
735-743
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotropic genetic effects contribute to this association. Therefore, data were analyzed from a total of 9662 major depressive disorder (MDD) cases and 14,949 controls (with no lifetime MDD diagnosis) from the Psychiatric Genomics Consortium with additional Dutch and Estonian data. The association of EA and MDD was assessed with logistic regression in 15,138 individuals indicating a significantly negative association in our sample with an odds ratio for MDD 0.78 (0.75-0.82) per standard deviation increase in EA. With data of 884,105 autosomal common single-nucleotide polymorphisms (SNPs), three methods were applied to test for pleiotropy between MDD and EA: (i) genetic profile risk scores (GPRS) derived from training data for EA (independent meta-analysis on ~120,000 subjects) and MDD (using a 10-fold leave-one-out procedure in the current sample), (ii) bivariate genomic-relationship-matrix restricted maximum likelihood (GREML) and (iii) SNP effect concordance analysis (SECA). With these methods, we found (i) that the EA-GPRS did not predict MDD status, and MDD-GPRS did not predict EA, (ii) a weak negative genetic correlation with bivariate GREML analyses, but this correlation was not consistently significant, (iii) no evidence for concordance of MDD and EA SNP effects with SECA analysis. To conclude, our study confirms an association of lower EA and MDD risk, but this association was not because of measurable pleiotropic genetic effects, which suggests that environmental factors could be involved, for example, socioeconomic status.

Mots-clé
Adult, Aged, Cohort Studies, Depressive Disorder, Major/epidemiology, Depressive Disorder, Major/genetics, Depressive Disorder, Major/psychology, Educational Status, Estonia/epidemiology, Female, Gene-Environment Interaction, Genetic Association Studies, Genotype, Humans, Likelihood Functions, Male, Middle Aged, Netherlands/epidemiology, Odds Ratio, Polymorphism, Single Nucleotide/genetics, Psychiatric Status Rating Scales, Regression Analysis
Pubmed
Création de la notice
04/02/2017 17:00
Dernière modification de la notice
20/08/2019 15:37
Données d'usage