Glial cells of the human fovea.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_7C0D87075B8D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Glial cells of the human fovea.
Périodique
Molecular vision
Auteur⸱e⸱s
Delaunay K., Khamsy L., Kowalczuk L., Moulin A., Nicolas M., Zografos L., Lassiaz P., Behar-Cohen F.
ISSN
1090-0535 (Electronic)
ISSN-L
1090-0535
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
26
Pages
235-245
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The exact cellular types that form the human fovea remain a subject of debate, and few studies have been conducted on human macula to solve this question. The purpose of this study was to perform immunohistochemistry on fresh human samples to characterize the glial cells that form the human fovea.
Immunohistochemistry was performed using antibodies against proteins expressed in astrocytes or in retinal Müller glial cells or both types of cells on six human macula obtained from eyes enucleated for peripheral intraocular tumors and on two postmortem eyes from healthy donors. The posterior poles of the enucleated eyes were cryosectioned and stained with antibodies against the glial proteins GFAP, vimentin, CRALBP, glutamine synthetase, and connexin 43.
A population of cells positive for GFAP and negative for glutamine synthetase and CRALBP that express connexin 43 were identified at the roof of the foveal pit. These cells are distinct from the Müller cone cells described by Yamada and Gass, suggesting that another type of foveal glial cells, most likely astrocytes, are present in the human fovea.
This study showed that in humans, astrocytic glial cells cover the foveal pit. Their roles in macula homeostasis and mechanisms of macular diseases disease remain to be determined.
Pubmed
Web of science
Création de la notice
25/04/2020 20:11
Dernière modification de la notice
15/01/2021 7:10
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