Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk.

Détails

Ressource 1Télécharger: koni-05-12-1240857.pdf (1714.14 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_7BCD9F561820
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Human melanomas and ovarian cancers overexpressing mechanical barrier molecule genes lack immune signatures and have increased patient mortality risk.
Périodique
Oncoimmunology
Auteur⸱e⸱s
Salerno E.P., Bedognetti D., Mauldin I.S., Deacon D.H., Shea S.M., Pinczewski J., Obeid J.M., Coukos G., Wang E., Gajewski T.F., Marincola F.M., Slingluff C.L.
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
5
Numéro
12
Pages
e1240857
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
We have identified eight genes whose expression in human melanoma metastases and ovarian cancers is associated with a lack of Th1 immune signatures. They encode molecules with mechanical barrier function in the skin and other normal tissues and include filaggrin (FLG), tumor-associated calcium signal transducer 2 (TACSTD2), and six desmosomal proteins (DST, DSC3, DSP, PPL, PKP3, and JUP). This association has been validated in an independent series of 114 melanoma metastases. In these, DST expression alone is sufficient to identify melanomas without immune signatures, while FLG and the other six putative barrier molecules are overexpressed in a different subset of melanomas lacking immune signatures. Similar associations have been identified in a set of 186 ovarian cancers. RNA-seq data from 471 melanomas and 307 ovarian cancers in the TCGA database further support these findings and also reveal that overexpression of barrier molecules is strongly associated with early patient mortality for melanoma (p = 0.0002) and for ovarian cancer (p < 0.01). Interestingly, this association persists for FLG for melanoma (p = 0.012) and ovarian cancer (p = 0.006), whereas DST overexpression is negatively associated with CD8(+) gene expression, but not with patient survival. Thus, overexpression of FLG or DST identifies two distinct patient populations with low immune cell infiltration in these cancers, but with different prognostic implications for each. These data raise the possibility that molecules with mechanical barrier function in skin and other tissues may be used by cancer cells to protect them from immune cell infiltration and immune-mediated destruction.

Pubmed
Web of science
Open Access
Oui
Création de la notice
07/02/2017 19:36
Dernière modification de la notice
20/08/2019 15:37
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