MANAGEMENT OF ENDOCRINE DISEASE: Reversible hypogonadotropic hypogonadism.

Détails

ID Serval
serval:BIB_7B491CDB3956
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
MANAGEMENT OF ENDOCRINE DISEASE: Reversible hypogonadotropic hypogonadism.
Périodique
European journal of endocrinology
Auteur⸱e⸱s
Dwyer A.A., Raivio T., Pitteloud N.
ISSN
1479-683X (Electronic)
ISSN-L
0804-4643
Statut éditorial
Publié
Date de publication
06/2016
Peer-reviewed
Oui
Volume
174
Numéro
6
Pages
R267-74
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Congenital hypogonadotropic hypogonadism (CHH) is characterized by lack of puberty and infertility. Traditionally, it has been considered a life-long condition yet cases of reversibility have been described wherein patients spontaneously recover function of the reproductive axis following treatment. Reversibility occurs in both male and female CHH cases and appears to be more common (~10-15%) than previously thought. These reversal patients span a range of GnRH deficiency from mild to severe and many reversal patients harbor mutations in genes underlying CHH. However, to date there are no clear factors for predicting reversible CHH. Importantly, recovery of reproductive axis function may not be permanent. Thus, CHH is not always life-long and the incidence of reversal warrants periodic treatment withdrawal with close monitoring and follow-up. Reversible CHH highlights the importance of environmental (epigenetic) factors such as sex steroid treatment on the reproductive axis in modifying the phenotype. This review provides an overview and an update on what is known about this phenomenon.

Mots-clé
Female, Humans, Hypogonadism/physiopathology, Male, Recovery of Function/physiology, Remission, Spontaneous
Pubmed
Open Access
Oui
Création de la notice
24/06/2016 20:24
Dernière modification de la notice
20/08/2019 15:37
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