Mortality Among Persons With Obsessive-Compulsive Disorder in Denmark.

Détails

ID Serval
serval:BIB_7AEF1B0DB94D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mortality Among Persons With Obsessive-Compulsive Disorder in Denmark.
Périodique
JAMA psychiatry
Auteur⸱e⸱s
Meier S.M., Mattheisen M., Mors O., Schendel D.E., Mortensen P.B., Plessen K.J.
ISSN
2168-6238 (Electronic)
ISSN-L
2168-622X
Statut éditorial
Publié
Date de publication
03/2016
Peer-reviewed
Oui
Volume
73
Numéro
3
Pages
268-274
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Several mental disorders have consistently been found to be associated with decreased life expectancy, but little is known about whether this is also the case for obsessive-compulsive disorder (OCD).
To determine whether persons who receive a diagnosis of OCD are at increased risk of death.
Using data from Danish registers, we conducted a nationwide prospective cohort study with 30 million person-years of follow-up. The data were collected from Danish longitudinal registers. A total of 3 million people born between 1955 and 2006 were followed up from January 1, 2002, through December 31, 2011. During this period, 27,236 people died. The data were analyzed primarily in June 2015.
We estimated mortality rate ratios (MRRs), adjusted for calendar year, age, sex, maternal and paternal age, place of residence at birth, and somatic comorbidities, to compare persons with OCT with persons without OCD.
Of 10,155 persons with OCD (5935 women and 4220 men with a mean [SD] age of 29.1 [11.3] years who contributed a total of 54,937 person-years of observation), 110 (1.1%) died during the average follow-up of 9.7 years. The risk of death by natural or unnatural causes was significantly higher among persons with OCD (MRR, 1.68 [95% CI, 1.31-2.12] for natural causes; MRR, 2.61 [95% CI, 1.91-3.47] for unnatural causes) than among the general population. After the exclusion of persons with comorbid anxiety disorders, depression, or substance use disorders, OCD was still associated with increased mortality risk (MRR, 1.88 [95% CI, 1.27-2.67]).
The presence of OCD was associated with a significantly increased mortality risk. Comorbid anxiety disorders, depression, or substance use disorders further increased the risk. However, after adjusting for these and somatic comorbidities, we found that the mortality risk remained significantly increased among persons with OCD.
Mots-clé
Adult, Aged, Cause of Death, Comorbidity, Denmark/epidemiology, Female, Humans, Life Expectancy, Longitudinal Studies, Male, Middle Aged, Obsessive-Compulsive Disorder/mortality, Prospective Studies, Registries, Risk Factors
Pubmed
Open Access
Oui
Création de la notice
14/02/2019 9:08
Dernière modification de la notice
20/08/2019 14:36
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