Added value of somato-sensory evoked potentials amplitude for prognostication after cardiac arrest.
Détails
ID Serval
serval:BIB_79E7411E70C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Added value of somato-sensory evoked potentials amplitude for prognostication after cardiac arrest.
Périodique
Resuscitation
ISSN
1873-1570 (Electronic)
ISSN-L
0300-9572
Statut éditorial
Publié
Date de publication
04/2020
Peer-reviewed
Oui
Volume
149
Pages
17-23
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Bilateral absence of cortical somato-sensory evoked potentials (SSEPs) robustly predicts poor outcome after cardiac arrest (CA), but it is uncertain if SSEP amplitudes provide additional information. Here, we examined the prognostic value of cortical SSEP amplitude in comparison with other known outcome predictors.
We retrospectively determined SSEP amplitudes in a prospective CA registry, identified an amplitude cut-off for worst Cerebral Performance Category (CPC) within three months, and examined correlations of SSEP amplitude with pupillary light reflex (PLR), myoclonus, peak serum neuron specific enolase (NSE), and 24-36 h and 36-72 h EEG (reactivity, epileptiform features).
Among 158 patients, 54% awoke. Amplitudes correlated with EEG findings, present PLR, myoclonus, NSE. A cut-off for cortical SSEP ≤ 0.41 μV was 100% specific for poor outcome (95% CI: 96-100%); sensitivity increased marginally vs. SSEPs absence [47% (35-59%) vs 46% (34-58%)] for CPC 4-5. Adding SSEPs ≤0.41 μV to a multimodal prognostic model including EEG, clinical features, and NSE improved prediction for mortality, but not for CPC 3-5 at three months. No statistical correlation between amplitudes and good outcome was observed. SSEP amplitudes correlated inversely with CPC at three months in the overall cohort (r = -0.332; p < 0.0001) but not in the subgroup with present SSEPs (r = -0.102; p = 0.256).
Decreased SSEPs amplitudes are associated with poor outcome after cardiac arrest; however, adding this to a multimodal prognostic approach including EEG, clinical and blood biomarkers, improves slightly prediction of mortality, but not of poor or good outcome.
We retrospectively determined SSEP amplitudes in a prospective CA registry, identified an amplitude cut-off for worst Cerebral Performance Category (CPC) within three months, and examined correlations of SSEP amplitude with pupillary light reflex (PLR), myoclonus, peak serum neuron specific enolase (NSE), and 24-36 h and 36-72 h EEG (reactivity, epileptiform features).
Among 158 patients, 54% awoke. Amplitudes correlated with EEG findings, present PLR, myoclonus, NSE. A cut-off for cortical SSEP ≤ 0.41 μV was 100% specific for poor outcome (95% CI: 96-100%); sensitivity increased marginally vs. SSEPs absence [47% (35-59%) vs 46% (34-58%)] for CPC 4-5. Adding SSEPs ≤0.41 μV to a multimodal prognostic model including EEG, clinical features, and NSE improved prediction for mortality, but not for CPC 3-5 at three months. No statistical correlation between amplitudes and good outcome was observed. SSEP amplitudes correlated inversely with CPC at three months in the overall cohort (r = -0.332; p < 0.0001) but not in the subgroup with present SSEPs (r = -0.102; p = 0.256).
Decreased SSEPs amplitudes are associated with poor outcome after cardiac arrest; however, adding this to a multimodal prognostic approach including EEG, clinical and blood biomarkers, improves slightly prediction of mortality, but not of poor or good outcome.
Mots-clé
Multimodal prognostication, Postanoxic coma, SSEPs amplitude
Pubmed
Création de la notice
14/02/2020 17:36
Dernière modification de la notice
07/04/2020 6:20