Theta-curves in proteins.
Détails
ID Serval
serval:BIB_79BE3BE60501
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Theta-curves in proteins.
Périodique
Protein science
ISSN
1469-896X (Electronic)
ISSN-L
0961-8368
Statut éditorial
Publié
Date de publication
09/2024
Peer-reviewed
Oui
Volume
33
Numéro
9
Pages
e5133
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
We study and characterize the topology of connectivity circuits observed in natively folded protein structures whose coordinates are deposited in the Protein Data Bank (PDB). Polypeptide chains of some proteins naturally fold into unique knotted configurations. Another kind of nontrivial topology of polypeptide chains is observed when, in addition to covalent bonds connecting consecutive amino acids in polypeptide chains, one also considers disulfide and ionic bonds between non-consecutive amino acids. Bonds between non-consecutive amino acids introduce bifurcation points into connectivity circuits defined by bonds between consecutive and nonconsecutive amino acids in analyzed proteins. Circuits with bifurcation points can form θ-curves with various topologies. We catalog here the observed topologies of θ-curves passing through bridges between consecutive and non-consecutive amino acids in studied proteins.
Mots-clé
Proteins/chemistry, Databases, Protein, Protein Folding, Models, Molecular, Protein Conformation, knotoids, knots, proteins, topology, θ‐curves
Pubmed
Open Access
Oui
Création de la notice
26/08/2024 10:56
Dernière modification de la notice
27/08/2024 6:19