Peroxisome proliferator-activated receptors and lipid metabolism.

Détails

ID Serval
serval:BIB_7909A0AB6A1E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Peroxisome proliferator-activated receptors and lipid metabolism.
Périodique
Annals of the New York Academy of Sciences
Auteur⸱e⸱s
Keller H., Mahfoudi A., Dreyer C., Hihi A.K., Medin J., Ozato K., Wahli W.
ISSN
0077-8923 (Print)
ISSN-L
0077-8923
Statut éditorial
Publié
Date de publication
1993
Volume
684
Pages
157-173
Langue
anglais
Résumé
PPARs are nuclear hormone receptors which, like the retinoid, thyroid hormone, vitamin D, and steroid hormone receptors, are ligand-activated transcription factors mediating the hormonal control of gene expression. Two lines of evidence indicate that PPARs have an important function in fatty acid metabolism. First, PPARs are activated by hypolipidemic drugs and physiological concentrations of fatty acids, and second, PPARs control the peroxisomal beta-oxidation pathway of fatty acids through transcriptional induction of the gene encoding the acyl-CoA oxidase (ACO), which is the rate-limiting enzyme of the pathway. Furthermore, the PPAR signaling pathway appears to converge with the 9-cis retinoic acid receptor (RXR) signaling pathway in the regulation of the ACO gene because heterodimerization between PPAR and RXR is essential for in vitro binding to the PPRE and because the strongest stimulation of this gene is observed when both receptors are exposed simultaneously to their activators. Thus, it appears that PPARs are involved in the 9-cis retinoic acid signaling pathway and that they play a pivotal role in the hormonal control of lipid metabolism.
Mots-clé
Acyl-CoA Oxidase, Animals, Base Sequence, DNA, Fatty Acids/physiology, Humans, Hypolipidemic Agents/pharmacology, Lipid Metabolism, Microbodies/metabolism, Molecular Sequence Data, Oxidoreductases/genetics, Oxidoreductases/metabolism, Receptors, Cell Surface/drug effects, Receptors, Cell Surface/metabolism, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Transcription Factors/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 16:04
Dernière modification de la notice
20/08/2019 14:35
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