A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Ried, J.S.; Jeff M, J.; Chu, A.Y.; Bragg-Gresham, J.L.; van Dongen, J.; Huffman, J.E.; Ahluwalia, T.S.; Cadby, G.; Eklund, N.; Eriksson, J.; Esko, T.; Feitosa, M.F.; Goel, A.; Gorski, M.; Hayward, C.; Heard-Costa, N.L.; Jackson, A.U.; Jokinen, E.; Kanoni, S.; Kristiansson, K.; Kutalik, Z.; Lahti, J.; Luan, J.; Mägi, R.; Mahajan, A.; Mangino, M.; Medina-Gomez, C.; Monda, K.L.; Nolte, I.M.; Pérusse, L.; Prokopenko, I.; Qi, L.; Rose, L.M.; Salvi, E.; Smith, M.T.; Snieder, H.; Stančáková, A.; Ju Sung, Y.; Tachmazidou, I.; Teumer, A.; Thorleifsson, G.; van der Harst, P.; Walker, R.W.; Wang, S.R.; Wild, S.H.; Willems, S.M.; Wong, A.; Zhang, W.; Albrecht, E.; Couto Alves, A.; Bakker, S.J.; Barlassina, C.; Bartz, T.M.; Beilby, J.; Bellis, C.; Bergman, R.N.; Bergmann, S.; Blangero, J.; Blüher, M.; Boerwinkle, E.; Bonnycastle, L.L.; Bornstein, S.R.; Bruinenberg, M.; Campbell, H.; Chen, Y.I.; Chiang, C.W.; Chines, P.S.; Collins, F.S.; Cucca, F.; Cupples, L.A.; D'Avila, F.; de Geus, E.J.; Dedoussis, G.; Dimitriou, M.; Döring, A.; Eriksson, J.G.; Farmaki, A.E.; Farrall, M.; Ferreira, T.; Fischer, K.; Forouhi, N.G.; Friedrich, N.; Gjesing, A.P.; Glorioso, N.; Graff, M.; Grallert, H.; Grarup, N.; Gräßler, J.; Grewal, J.; Hamsten, A.; Harder, M.N.; Hartman, C.A.; Hassinen, M.; Hastie, N.; Hattersley, A.T.; Havulinna, A.S.; Heliövaara, M.; Hillege, H.; Hofman, A.; Holmen, O.; Homuth, G.; Hottenga, J.J.; Hui, J.; Husemoen, L.L.; Hysi, P.G.; Isaacs, A.; Ittermann, T.; Jalilzadeh, S.; James, A.L.; Jørgensen, T.; Jousilahti, P.; Jula, A.; Marie Justesen, J.; Justice, A.E.; Kähönen, M.; Karaleftheri, M.; Tee Khaw, K.; Keinanen-Kiukaanniemi, S.M.; Kinnunen, L.; Knekt, P.B.; Koistinen, H.A.; Kolcic, I.; Kooner, I.K.; Koskinen, S.; Kovacs, P.; Kyriakou, T.; Laitinen, T.; Langenberg, C.; Lewin, A.M.; Lichtner, P.; Lindgren, C.M.; Lindström, J.; Linneberg, A.; Lorbeer, R.; Lorentzon, M.; Luben, R.; Lyssenko, V.; Männistö, S.; Manunta, P.; Leach, I.M.; McArdle, W.L.; Mcknight, B.; Mohlke, K.L.; Mihailov, E.; Milani, L.; Mills, R.; Montasser, M.E.; Morris, A.P.; Müller, G.; Musk, A.W.; Narisu, N.; Ong, K.K.; Oostra, B.A.; Osmond, C.; Palotie, A.; Pankow, J.S.; Paternoster, L.; Penninx, B.W.; Pichler, I.; Pilia, M.G.; Polašek, O.; Pramstaller, P.P.; Raitakari, O.T.; Rankinen, T.; Rao, D.C.; Rayner, N.W.; Ribel-Madsen, R.; Rice, T.K.; Richards, M.; Ridker, P.M.; Rivadeneira, F.; Ryan, K.A.; Sanna, S.; Sarzynski, M.A.; Scholtens, S.; Scott, R.A.; Sebert, S.; Southam, L.; Sparsø, T.H.; Steinthorsdottir, V.; Stirrups, K.; Stolk, R.P.; Strauch, K.; Stringham, H.M.; Swertz, M.A.; Swift, A.J.; Tönjes, A.; Tsafantakis, E.; van der Most, P.J.; Van Vliet-Ostaptchouk, J.V.; Vandenput, L.; Vartiainen, E.; Venturini, C.; Verweij, N.; Viikari, J.S.; Vitart, V.; Vohl, M.C.; Vonk, J.M.; Waeber, G.; Widén, E.; Willemsen, G.; Wilsgaard, T.; Winkler, T.W.; Wright, A.F.; Yerges-Armstrong, L.M.; Hua Zhao, J.; Carola Zillikens, M.; Boomsma, D.I.; Bouchard, C.; Chambers, J.C.; Chasman, D.I.; Cusi, D.; Gansevoort, R.T.; Gieger, C.; Hansen, T.; Hicks, A.A.; Hu, F.; Hveem, K.; Jarvelin, M.R.; Kajantie, E.; Kooner, J.S.; Kuh, D.; Kuusisto, J.; Laakso, M.; Lakka, T.A.; Lehtimäki, T.; Metspalu, A.; Njølstad, I.; Ohlsson, C.; Oldehinkel, A.J.; Palmer, L.J.; Pedersen, O.; Perola, M.; Peters, A.; Psaty, B.M.; Puolijoki, H.; Rauramaa, R.; Rudan, I.; Salomaa, V.; Schwarz, P.E.; Shudiner, A.R.; Smit, J.H.; Sørensen, T.I.; Spector, T.D.; Stefansson, K.; Stumvoll, M.; Tremblay, A.; Tuomilehto, J.; Uitterlinden, A.G.; Uusitupa, M.; Völker, U.; Vollenweider, P.; Wareham, N.J.; Watkins, H.; Wilson, J.F.; Zeggini, E.; Abecasis, G.R.; Boehnke, M.; Borecki, I.B.; Deloukas, P.; van Duijn, C.M.; Fox, C.; Groop, L.C.; Heid, I.M.; Hunter, D.J.; Kaplan, R.C.; McCarthy, M.I.; North, K.E.; O'Connell, J.R.; Schlessinger, D.; Thorsteinsdottir, U.; Strachan, D.P.; Frayling, T.; Hirschhorn, J.N.; Müller-Nurasyid, M.; Loos, R.J.

doi:10.1038/ncomms13357

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Détails

Télécharger: BIB_785C16F5A5CA.pdf (836.49 [Ko])
Etat: Public
Version: Final published version

ID Serval

serval:BIB_785C16F5A5CA

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Périodique

Nature communications

Auteur⸱e⸱s

Ried J.S., Jeff M J., Chu A.Y., Bragg-Gresham J.L., van Dongen J., Huffman J.E., Ahluwalia T.S., Cadby G., Eklund N., Eriksson J., Esko T., Feitosa M.F., Goel A., Gorski M., Hayward C., Heard-Costa N.L., Jackson A.U., Jokinen E., Kanoni S., Kristiansson K., Kutalik Z., Lahti J., Luan J., Mägi R., Mahajan A., Mangino M., Medina-Gomez C., Monda K.L., Nolte I.M., Pérusse L., Prokopenko I., Qi L., Rose L.M., Salvi E., Smith M.T., Snieder H., Stančáková A., Ju Sung Y., Tachmazidou I., Teumer A., Thorleifsson G., van der Harst P., Walker R.W., Wang S.R., Wild S.H., Willems S.M., Wong A., Zhang W., Albrecht E., Couto Alves A., Bakker S.J., Barlassina C., Bartz T.M., Beilby J., Bellis C., Bergman R.N., Bergmann S., Blangero J., Blüher M., Boerwinkle E., Bonnycastle L.L., Bornstein S.R., Bruinenberg M., Campbell H., Chen Y.I., Chiang C.W., Chines P.S., Collins F.S., Cucca F., Cupples L.A., D'Avila F., de Geus E.J., Dedoussis G., Dimitriou M., Döring A., Eriksson J.G., Farmaki A.E., Farrall M., Ferreira T., Fischer K., Forouhi N.G., Friedrich N., Gjesing A.P., Glorioso N., Graff M., Grallert H., Grarup N., Gräßler J., Grewal J., Hamsten A., Harder M.N., Hartman C.A., Hassinen M., Hastie N., Hattersley A.T., Havulinna A.S., Heliövaara M., Hillege H., Hofman A., Holmen O., Homuth G., Hottenga J.J., Hui J., Husemoen L.L., Hysi P.G., Isaacs A., Ittermann T., Jalilzadeh S., James A.L., Jørgensen T., Jousilahti P., Jula A., Marie Justesen J., Justice A.E., Kähönen M., Karaleftheri M., Tee Khaw K., Keinanen-Kiukaanniemi S.M., Kinnunen L., Knekt P.B., Koistinen H.A., Kolcic I., Kooner I.K., Koskinen S., Kovacs P., Kyriakou T., Laitinen T., Langenberg C., Lewin A.M., Lichtner P., Lindgren C.M., Lindström J., Linneberg A., Lorbeer R., Lorentzon M., Luben R., Lyssenko V., Männistö S., Manunta P., Leach I.M., McArdle W.L., Mcknight B., Mohlke K.L., Mihailov E., Milani L., Mills R., Montasser M.E., Morris A.P., Müller G., Musk A.W., Narisu N., Ong K.K., Oostra B.A., Osmond C., Palotie A., Pankow J.S., Paternoster L., Penninx B.W., Pichler I., Pilia M.G., Polašek O., Pramstaller P.P., Raitakari O.T., Rankinen T., Rao D.C., Rayner N.W., Ribel-Madsen R., Rice T.K., Richards M., Ridker P.M., Rivadeneira F., Ryan K.A., Sanna S., Sarzynski M.A., Scholtens S., Scott R.A., Sebert S., Southam L., Sparsø T.H., Steinthorsdottir V., Stirrups K., Stolk R.P., Strauch K., Stringham H.M., Swertz M.A., Swift A.J., Tönjes A., Tsafantakis E., van der Most P.J., Van Vliet-Ostaptchouk J.V., Vandenput L., Vartiainen E., Venturini C., Verweij N., Viikari J.S., Vitart V., Vohl M.C., Vonk J.M., Waeber G., Widén E., Willemsen G., Wilsgaard T., Winkler T.W., Wright A.F., Yerges-Armstrong L.M., Hua Zhao J., Carola Zillikens M., Boomsma D.I., Bouchard C., Chambers J.C., Chasman D.I., Cusi D., Gansevoort R.T., Gieger C., Hansen T., Hicks A.A., Hu F., Hveem K., Jarvelin M.R., Kajantie E., Kooner J.S., Kuh D., Kuusisto J., Laakso M., Lakka T.A., Lehtimäki T., Metspalu A., Njølstad I., Ohlsson C., Oldehinkel A.J., Palmer L.J., Pedersen O., Perola M., Peters A., Psaty B.M., Puolijoki H., Rauramaa R., Rudan I., Salomaa V., Schwarz P.E., Shudiner A.R., Smit J.H., Sørensen T.I., Spector T.D., Stefansson K., Stumvoll M., Tremblay A., Tuomilehto J., Uitterlinden A.G., Uusitupa M., Völker U., Vollenweider P., Wareham N.J., Watkins H., Wilson J.F., Zeggini E., Abecasis G.R., Boehnke M., Borecki I.B., Deloukas P., van Duijn C.M., Fox C., Groop L.C., Heid I.M., Hunter D.J., Kaplan R.C., McCarthy M.I., North K.E., O'Connell J.R., Schlessinger D., Thorsteinsdottir U., Strachan D.P., Frayling T., Hirschhorn J.N., Müller-Nurasyid M., Loos R.J.

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Statut éditorial

Publié

Date de publication

23/11/2016

Volume

Pages

13357

Langue

anglais

Notes

Publication types: Journal Article
Publication Status: epublish

Résumé

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.

URN

urn:nbn:ch:serval-BIB_785C16F5A5CA6

OAI-PMH

oai:serval.unil.ch:BIB_785C16F5A5CA

DOI

10.1038/ncomms13357

Pubmed

27876822

Open Access

Oui

Création de la notice

02/12/2016 12:40