Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy : a randomized controlled trial

Détails

Ressource 1Télécharger: BIB_782203525412.P001.pdf (442.85 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_782203525412
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy : a randomized controlled trial
Périodique
Critical Care (london, England)
Auteur⸱e⸱s
Stucker F., Ponte B., Tataw J., Martin P.Y., Wozniak H., Pugin J., Saudan P.
ISSN
1466-609X (Electronic)
ISSN-L
1364-8535
Statut éditorial
Publié
Date de publication
12/2015
Peer-reviewed
Oui
Volume
19
Numéro
1
Pages
91
Langue
anglais
Notes
Publication Status: epublish. - IUMSP2015/12
Résumé
INTRODUCTION: A systemic anticoagulation is often required to prevent circuit and filter clotting in ICU patients undergoing continuous renal replacement therapy (CRRT). A regional citrate-based anticoagulation (RCA) does not induce a systemic anticoagulation and prolongs the filter lifespan, but metabolic side-effects have been associated with this therapy. We conducted a randomized controlled trial with patients requiring CRRT to determine whether RCA using a balanced predilution replacement fluid is more effective than heparin in terms of renal replacement delivered dose and safety profile.
METHODS: One hundred and three patients with AKI requiring CRRT were included. The patients were randomized to either CRRT with RCA or heparin anticoagulation. Primary endpoints were effective daily delivered RRT dose during the first 3 days of CRRT and filter lifespan. Secondary endpoints were 28-day and 90-day survival and severe metabolic complications and bleeding disorders.
RESULTS: Median CRRT duration was 3.0 (2-6) days. Effective delivered daily RRT doses were 29 ± 3 and 27 ± 5 mL/kg/hr in the RCA and heparin groups, respectively (p = 0.005). Filter lifespans were 49 ± 29 versus 28 ± 23 hrs in the RCA and heparin groups (p = 0.004). Survival rates at 28 and 90 days were 80-74% in the RCA and 74-73% in the heparin group. Electrolytes and acid-base disturbances were uncommon and transient in patients treated with RCA.
CONCLUSIONS: These results show that RCA is superior to heparin-based anticoagulation in terms of delivered RRT dose and filter life span and is a safe and feasible method. This does not translate into an improvement in short term survival.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01269112 . Registered 3rd January 2011.
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/05/2015 9:59
Dernière modification de la notice
20/08/2019 14:34
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