Postoperative Albumin Drop Is a Marker for Surgical Stress and a Predictor for Clinical Outcome: A Pilot Study.

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ID Serval
serval:BIB_76B5565FAAE7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Postoperative Albumin Drop Is a Marker for Surgical Stress and a Predictor for Clinical Outcome: A Pilot Study.
Périodique
Gastroenterology Research and Practice
Auteur(s)
Hübner M., Mantziari S., Demartines N., Pralong F., Coti-Bertrand P., Schäfer M.
ISSN
1687-6121 (Print)
ISSN-L
1687-6121
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
2016
Pages
8743187
Langue
anglais
Résumé
Background. Surgical stress during major surgery may be related to adverse clinical outcomes and early quantification of stress response would be useful to allow prompt interventions. The aim of this study was to evaluate the acute phase protein albumin in the context of the postoperative stress response. Methods. This prospective pilot study included 70 patients undergoing frequent abdominal procedures of different magnitude. Albumin (Alb) and C-reactive protein (CRP) levels were measured once daily starting the day before surgery until postoperative day (POD) 5. Maximal Alb decrease (Alb Δ min) was correlated with clinical parameters of surgical stress, postoperative complications, and length of stay. Results. Albumin values dropped immediately after surgery by about 10 g/L (42.2 ± 4.5 g/L preoperatively versus 33.8 ± 5.3 g/L at day 1, P < 0.001). Alb Δ min was correlated with operation length (Pearson ρ = 0.470, P < 0.001), estimated blood loss (ρ = 0.605, P < 0.001), and maximal CRP values (ρ = 0.391, P = 0.002). Alb Δ min levels were significantly higher in patients having complications (10.0 ± 5.4 versus 6.1 ± 5.2, P = 0.005) and a longer hospital stay (ρ = 0.285, P < 0.020). Conclusion. Early postoperative albumin drop appeared to reflect the magnitude of surgical trauma and was correlated with adverse clinical outcomes. Its promising role as early marker for stress response deserves further prospective evaluation.
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/02/2016 17:41
Dernière modification de la notice
20/08/2019 15:33
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