In vivo magnetic resonance spectroscopy of human brain: the biophysical basis of dementia.

Détails

ID Serval
serval:BIB_76A9DB94848D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
In vivo magnetic resonance spectroscopy of human brain: the biophysical basis of dementia.
Périodique
Biophysical Chemistry
Auteur⸱e⸱s
Ross B.D., Bluml S., Cowan R., Danielsen E., Farrow N., Gruetter R.
ISSN
0301-4622 (Print)
ISSN-L
0301-4622
Statut éditorial
Publié
Date de publication
1997
Volume
68
Numéro
1-3
Pages
161-172
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Nuclear magnetic resonance spectroscopy (MRS) in low and medium magnetic fields yields well-resolved natural abundance proton and decoupled phosphorus spectra from small (1-10 cc) volumes of brain in vivo in minutes. With this tool, neurochemical research has advanced through identification and non-invasive assay of specific neuronal--(N-acetylaspartate), glial (myo-inositol)--markers, energetics and osmolytes, and neurotransmitters (glutamate, GABA). From these simple measurements, several dozen disease states are recognized, including birth injury, and white matter and Alzheimer disease. Addition of stable isotopes of carbon (in man) or nitrogen (in experimental animals) has provided in vivo assays of enzyme flux through glucose transport, glycolysis, TCA-cycle, and the glutamine-glutamate-GABA system. Finally, a number of xenobiotics are recognized with heteronuclear NMR techniques. Together, these tools are having a major impact on neuroscience and clinical medicine. Through diagnosis and therapeutic monitoring, a new generation of in vivo metabolite imaging is expected with the advent of conforming RF coils and higher field NMR systems.
Mots-clé
Animals, Biophysical Phenomena, Biophysics, Brain/metabolism, Dementia/diagnosis, Dementia/metabolism, Humans, Nuclear Magnetic Resonance, Biomolecular/methods
Pubmed
Web of science
Création de la notice
04/08/2010 15:28
Dernière modification de la notice
20/08/2019 14:33
Données d'usage