Outcome of seizures in the general population after 25 years: a prospective follow-up, observational cohort study.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_76A682153010
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Outcome of seizures in the general population after 25 years: a prospective follow-up, observational cohort study.
Périodique
Journal of neurology, neurosurgery, and psychiatry
Auteur(s)
Bell G.S., Neligan A., Giavasi C., Keezer M.R., Novy J., Peacock J.L., Johnson A.L., Goodridge D.M., Shorvon S.D., Sander J.W.
ISSN
1468-330X (Electronic)
ISSN-L
0022-3050
Statut éditorial
Publié
Date de publication
08/2016
Peer-reviewed
Oui
Volume
87
Numéro
8
Pages
843-850
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We investigated long-term (to 25 years) seizure prognosis and survival in people with newly diagnosed epilepsy in the community. We explored whether prognosis is different in those with epilepsy (>2 unprovoked seizures) and those with a single seizure at presentation.
This is a prospective observational cohort study of people with newly diagnosed seizures. We investigated seizure outcome and survival in people presenting with a single seizure and in those presenting with >2 seizures (epilepsy).
695 people (median follow-up 23.6 years) had unprovoked epileptic seizures. For seizure analysis we excluded 38 people with missing data leaving 657 (309 male, and 249 aged <18 years). Seizures recurred in 67%. The 354 people with epilepsy were only slightly more likely to have further seizure recurrence than the 302 people with a single seizure at presentation (HR 1.32, 95% CI 1.09 to 1.59). In 327 people with complete follow-up, 268 (82%, 95% CI 77% to 86%) were in terminal remission; (80%, (95% CI 73% to 85%) in those with epilepsy at presentation). Premature mortality was increased in people with epilepsy (standardised mortality ratio 1.67; 95% CI 1.40 to 1.99) and those with a single seizure at presentation (standardised mortality ratio 2.65; 95% CI 2.23 to 3.15). It is also high in those with early remission.
People with epilepsy and with single seizures at presentation in the community generally have good prognosis for seizure control with prolonged follow-up. The risk of premature mortality is significantly increased in both groups.

Pubmed
Web of science
Open Access
Oui
Création de la notice
06/10/2016 13:24
Dernière modification de la notice
20/08/2019 15:33
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