Atenolol in der Behandlung der Angina pectoris. [Atenolol in the treatment of angina pectoris]

Détails

ID Serval
serval:BIB_76A676A6CDDF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Atenolol in der Behandlung der Angina pectoris. [Atenolol in the treatment of angina pectoris]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Bachmann  M., Raeber  E., Burckhardt  D., Schwytzer  F., Munch  U., Kappenberger  L., Nager  F.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
12/1979
Volume
109
Numéro
47
Pages
1857-60
Notes
Clinical Trial
Comparative Study
Controlled Clinical Trial
English Abstract
Journal Article --- Old month value: Dec 8
Résumé
18 patients with angina pectoris participated in a double blind trial with atenolol (100 mg and 200 mg once daily, or 100 mg twice daily) and propranolol (80 mg twice daily). The number of anginal attacks (NAP), the number of days free of pain (NAFT), consumption of sublingual nitroglycerin (NNT) and bicycle ergometry data (EFE) were recorded. Atenolol given in a dose of 100 g twice daily significantly reduced NAP and NNT as compared with the other dose schedules for atenolol and propranolol. There was, however, no difference between NAFT and EFE under any of the treatment schedules mentioned above. Only with 100 mg atenolol twice daily was it possible to reduce heart rate at rest and immediately after exercise testing, and also diastolic blood pressure (at rest, upright and after stress testing). In spite of the long plasma T 1/2 (= 24 hours) reported by others, atenolol given twice daily seems to be the most effective schedule. It is concluded that atenolol (100 mg twice daily) has a more potent anti-anginal effect than propranolol (80 mg twice daily). In addition, atenolol has the advantage of being cardioselective.
Mots-clé
Aged Angina Pectoris/*drug therapy Atenolol/*therapeutic use Double-Blind Method Drug Evaluation Exertion Female Humans Male Middle Aged Propanolamines/*therapeutic use Propranolol/therapeutic use
Pubmed
Web of science
Création de la notice
15/02/2008 12:28
Dernière modification de la notice
20/08/2019 15:33
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