Immune responses to gene-modified T cells

Détails

ID Serval
serval:BIB_75E913A1B646
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immune responses to gene-modified T cells
Périodique
Curr Gene Ther
Auteur⸱e⸱s
Muul L. M., Candotti F.
ISSN
1566-5232 (Print)
ISSN-L
1566-5232
Statut éditorial
Publié
Date de publication
10/2007
Volume
7
Numéro
5
Pages
361-8
Langue
anglais
Notes
Muul, Linda Mesler
Candotti, Fabio
eng
Intramural NIH HHS/
Research Support, N.I.H., Intramural
Review
Netherlands
Curr Gene Ther. 2007 Oct;7(5):361-8.
Résumé
Gene-modified T cells were the first gene therapy tool used in clinical gene transfer trials. After the first applications in immunodeficiency diseases, T cell gene therapy has been extended to HIV infection and cancer. The primary obstacle to successful T cell gene therapy has proven to be the robust immune responses elicited by the gene-modified T cells even in severely immunosuppressed patients. The potent antibody and cytotoxic immune responses have interfered with the expression and persistence of the therapeutic transgene. In this review we will address each of the components of T cell gene therapy -- culture conditions, vector, and transgene -- that have elicited these immune responses and the strategies used to minimize them.
Mots-clé
Animals, Antibody Formation/*immunology, Cell Culture Techniques, Cell- and Tissue-Based Therapy, Child, Cytotoxicity, Immunologic/immunology, Dendritic Cells, Gene Transfer Techniques, Genetic Therapy/*methods, Genetic Vectors/administration & dosage/*immunology, Host vs Graft Reaction/genetics/*immunology, Humans, Immunity, Cellular, *Immunotherapy, Adoptive, Metabolic Diseases/therapy, Mice, Neoplasms/therapy, T-Lymphocytes/*immunology/metabolism/*transplantation, Transduction, Genetic, Transgenes/immunology
Pubmed
Création de la notice
01/11/2017 11:29
Dernière modification de la notice
20/08/2019 15:33
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