Brain-muscle interplay during endurance self-paced exercise in normobaric and hypobaric hypoxia.

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_75E6EC29DBAA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Brain-muscle interplay during endurance self-paced exercise in normobaric and hypobaric hypoxia.
Périodique
Frontiers in physiology
Auteur⸱e⸱s
Rupp T., Saugy J.J., Bourdillon N., Millet G.P.
ISSN
1664-042X (Print)
ISSN-L
1664-042X
Statut éditorial
Publié
Date de publication
2022
Peer-reviewed
Oui
Volume
13
Pages
893872
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Purpose: Hypoxia is one major environmental factor, supposed to mediate central motor command as well as afferent feedbacks at rest and during exercise. By using a comparison of normobaric (NH) and hypobaric (HH) hypoxia with the same ambient pressure in oxygen, we examined the potential differences on the cerebrovascular and muscular regulation interplay during a self-paced aerobic exercise. Methods: Sixteen healthy subjects performed three cycling time-trials (250 kJ) in three conditions: HH, NH and normobaric normoxia (NN) after 24 h of exposure. Cerebral and muscular oxygenation were assessed by near-infrared spectroscopy, cerebral blood flow by Doppler ultrasound system. Gas exchanges, peripheral oxygen saturation, power output and associated pacing strategies were also continuously assessed. Results: The cerebral oxygen delivery was lower in hypoxia than in NN but decreased similarly in both hypoxic conditions. Overall performance and pacing were significantly more down-regulated in HH versus NH, in conjunction with more impaired systemic (e.g. saturation and cerebral blood flow) and prefrontal cortex oxygenation during exercise. Conclusions: The difference in pacing was likely the consequence of a complex interplay between systemic alterations and cerebral oxygenation observed in HH compared to NH, aiming to maintain an equivalent cerebral oxygen delivery despite higher adaptive cost (lower absolute power output for the same relative exercise intensity) in HH compared to NH.
Mots-clé
altitude, cerebral oxygen delivery, near-infrared spectroscopy, pacing strategies, performance, time-trial exercise
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/07/2022 17:35
Dernière modification de la notice
16/03/2023 6:47
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