Clinically "small" effects of air pollution on FVC have a large public health impact. Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) - team

Détails

ID Serval
serval:BIB_75D2C67D3473
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinically "small" effects of air pollution on FVC have a large public health impact. Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) - team
Périodique
European Respiratory Journal
Auteur⸱e⸱s
Kunzli  N., Ackermann-Liebrich  U., Brandli  O., Tschopp  J. M., Schindler  C., Leuenberger  P.
ISSN
0903-1936 (Print)
Statut éditorial
Publié
Date de publication
01/2000
Volume
15
Numéro
1
Pages
131-6
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jan
Résumé
Epidemiological studies have repeatedly established adverse health effects due to long-term exposure to ambient air pollution. The Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) published a -3.14% decrease in forced vital capacity (FVC) per 10 microg x m(-3) increment in particulate matter (particles with a 50% cut-off aerodynamic diameter of 10 microm (PM(10)). Compared to the within-subject variability of FVC, the effect may be considered small. This individual (or clinical) perspective is, however, misleading. The purpose of this study was to demonstrate the public health relevance of apparently "small" effects, using the impact of PM10 on FVC as an example. The scenario compares a population A, exposed to an annual mean PM10 of 20 microg x m(-3), with a population B exposed to 30 microg x m(-3) mean PM10. A shift of -3.14% in the population distribution of FVC increases the number of subjects in the lower tail of the distribution. In population B a relative increase was expected of 47% (16-91%) in the prevalence of "FVC <80% predicted", (i.e., from 5.17 to 7.59% and 5.88 to 8.65% among males and females, respectively). The relative increase in the prevalence of "FVC <70% predicted" (approximately 1% of population) was 63% (30-98%, males) and 57% (21-86%, females). An epidemiological estimate of a change in the mean value of the population distribution should not be misinterpreted as an effect on the individual level. However, the impact of a 10 microg x m(-3) increase in particles with a 50% cut-off aerodynamic diameter of 10 microm (PM10) on the number of subjects with a clinically relevant reduction in lung function is quantitatively important.
Mots-clé
Adult Air Pollution/*adverse effects Asthma/etiology Environmental Monitoring Female Humans Male Maximum Allowable Concentration Particle Size *Public Health Vital Capacity/*drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 9:50
Dernière modification de la notice
20/08/2019 14:33
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