Determination of p53 mutations, EGFR overexpression, and loss of p16 expression in pediatric glioblastomas

Détails

ID Serval
serval:BIB_753FFB896E64
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Determination of p53 mutations, EGFR overexpression, and loss of p16 expression in pediatric glioblastomas
Périodique
Journal of Neuropathology and Experimental Neurology
Auteur(s)
Sure  U., Ruedi  D., Tachibana  O., Yonekawa  Y., Ohgaki  H., Kleihues  P., Hegi  M. E.
ISSN
0022-3069 (Print)
Statut éditorial
Publié
Date de publication
07/1997
Volume
56
Numéro
7
Pages
782-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
Glioblastoma multiforme is a rare neoplasm in children and is often located infratentorially, particularly in the brainstem: Pediatric glioblastomas arise frequently (here 60%) outside the cerebral hemispheres. We investigated 20 pediatric glioblastomas for mutational inactivation of the p53 tumor suppressor gene, loss of p16 protein expression and overexpression of the epidermal growth factor receptor (EGFR). Mutations in the p53 gene were identified in 5/20 (25%) glioblastomas, 4 of which occurred in primary glioblastomas with a clinical history of less than 4 months and neither clinical nor histologic evidence of a less malignant precursor lesion. Loss of p16 expression was detected in 11/18 (61%) glioblastomas. Overexpression of the EGFR was infrequent (2/19, 11%) and included 1 tumor with a p53 mutation. Of 4 secondary glioblastomas that progressed from histologically diagnosed lower grade tumors, one contained a p53 mutation. Our results are at variance with similar studies in adult patients in which primary and secondary glioblastomas are characterized by EGFR overexpression and p53 mutations, respectively, suggesting that the evolution of pediatric glioblastomas follows different genetic pathways.
Mots-clé
Adolescent Brain Neoplasms/*genetics Carrier Proteins/*genetics Child Child, Preschool Cyclin-Dependent Kinase Inhibitor p16 Female Gene Expression/*genetics Genes, Tumor Suppressor/*genetics Genes, p53/*genetics Glioblastoma/*genetics Humans Immunohistochemistry Infant Male Receptor, Epidermal Growth Factor/*genetics
Pubmed
Web of science
Création de la notice
25/01/2008 13:05
Dernière modification de la notice
20/08/2019 14:32
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