Aurora A Kinase as a diagnostic urinary marker for urothelial bladder cancer.

Détails

ID Serval
serval:BIB_753C4BCA872D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Aurora A Kinase as a diagnostic urinary marker for urothelial bladder cancer.
Périodique
World journal of urology
Auteur⸱e⸱s
de Martino M., Shariat S.F., Hofbauer S.L., Lucca I., Taus C., Wiener H.G., Haitel A., Susani M., Klatte T.
ISSN
1433-8726 (Electronic)
ISSN-L
0724-4983
Statut éditorial
Publié
Date de publication
01/2015
Peer-reviewed
Oui
Volume
33
Numéro
1
Pages
105-110
Langue
anglais
Notes
Publication types: Clinical Study ; Journal Article
Publication Status: ppublish
Résumé
To evaluate urinary Aurora A Kinase (AURKA) mRNA expression as a diagnostic biomarker for urothelial bladder cancer (UBC).
One hundred and eighty-eight urine samples from patients with UBC (n = 122) and controls with hematuria (n = 66) were investigated. AURKA expression was quantified using real-time PCR and compared with voided urinary cytology. Associations with stage and grade were assessed. The area under curve was used to quantify the predictive accuracy (PA).
The sensitivity and the specificity of AURKA for UBC were 83.6 and 65.2 %, respectively (PA = 74.4 %). Among those with detectable AURKA, the quantity of expression was similar in cases and controls. Compared with Ta, tumors staged T1 and T2 showed a 9.31-fold and 4.78-fold increased AURKA expression (p = 0.034), respectively. Further, high-grade tumors showed 5.33-fold higher expression levels than low-grade tumors (p = 0.031). AURKA and urinary cytology showed similar overall PA for UBC detection (74.4 vs. 72.1 %, p = 0.588). For low-grade tumors, AURKA was more accurate (72.5 vs. 59.0 %, p = 0.004), while cytology was more accurate for high-grade lesions (76.8 vs. 89.1 %, p = 0.011).
In patients with hematuria, AURKA is associated with the presence and grade of UBC, suggesting a role as diagnostic and prognostic biomarker. As AURKA is more accurate in low-grade tumors but less accurate in high-grade tumors than urinary cytology, both could be complementary in detecting UBC.
Mots-clé
Adult, Aged, Aurora Kinase A/genetics, Aurora Kinase A/urine, Biomarkers/urine, Case-Control Studies, Female, Humans, Male, Middle Aged, Neoplasm Grading, Neoplasm Staging, Predictive Value of Tests, RNA, Messenger/urine, ROC Curve, Real-Time Polymerase Chain Reaction, Urinary Bladder Neoplasms/diagnosis, Urinary Bladder Neoplasms/genetics, Urinary Bladder Neoplasms/urine, Urothelium
Pubmed
Web of science
Création de la notice
17/12/2018 16:26
Dernière modification de la notice
20/08/2019 14:32
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