Primary malignant mixed Mullerian tumor (metaplastic carcinoma) of the female peritoneum. A clinical, pathologic, and immunohistochemical study of three cases and a review of the literature

Détails

ID Serval
serval:BIB_751F3B84F13E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Primary malignant mixed Mullerian tumor (metaplastic carcinoma) of the female peritoneum. A clinical, pathologic, and immunohistochemical study of three cases and a review of the literature
Périodique
Cancer
Auteur⸱e⸱s
Garamvoelgyi  E., Guillou  L., Gebhard  S., Salmeron  M., Seematter  R. J., Hadji  M. H.
ISSN
0008-543X (Print)
Statut éditorial
Publié
Date de publication
1994
Volume
74
Numéro
3
Pages
854-863
Notes
PT - Case Reports PT - Journal Article PT - Review
Résumé
BACKGROUND. Malignant mixed mesodermal tumors (malignant mixed Mullerian tumors [MMMT]) occur rarely in extragenital sites. METHODS. The authors analyzed the clinical, pathologic, and immunohistochemical features of three cases of primary MMMT of the female peritoneum. RESULTS. The neoplasms occurred in 60-, 64- and 84-year-old women and arose from pelvic peritoneum. Two patients died with disseminated disease 8 and 24 months postoperatively. The third died of cardiac failure 12 months postoperatively with questionable metastatic disease. Microscopically, two tumors were of the heterologous type, containing foci of rhabdomyosarcomatous (case 1) and chondrosarcomatous (case 3) differentiation. Immunohistochemically, coexpression of keratin and vimentin was observed focally in both carcinomatous and sarcomatous components in all three neoplasms, whereas coexpression of low molecular weight cytokeratin, vimentin and actin was observed focally in case 2. Rhabdomyosarcomatous areas were positive with desmin and actin, and chondrosarcomatous areas for S-100 protein. Both epithelial and mesenchymal components were positive for alpha-1 antichymotrypsin in all cases. CONCLUSIONS. On the basis of the present cases and a review of 15 reports from the literature, primary MMMT of the female peritoneum proved to be a rare but highly malignant neoplasm occurring in elderly postmenopausal women. Of 15 patients with available follow-up, 12 died with disease, mostly within 1 year, regardless of the initial tumor stage, histology (homologous versus heterologous MMMT) or treatments attempted. The tumor developed within pelvic peritoneum in half the cases. Histogenetically, peritoneal MMMT are thought to represent "metaplastic" carcinomas originating from the secondary Mullerian system
Mots-clé
Actins/analysis/Aged/Aged,80 and over/Chondrosarcoma/Pathology/Desmin/Female/Humans/Immunohistochemistry/Keratins/Middle Aged/Mixed Tumor,Mullerian/chemistry/mortality/Peritoneal Neoplasms/Prognosis/Rhabdomyosarcoma/S100 Proteins/Vimentin/alpha 1-Antichymotrypsin
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 19:33
Dernière modification de la notice
20/08/2019 15:32
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