Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Détails

Ressource 1Télécharger: BIB_749211F19289.P001.pdf (1494.67 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_749211F19289
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Périodique
Nature genetics
Auteur⸱e⸱s
Okbay A., Baselmans B.M., De Neve J.E., Turley P., Nivard M.G., Fontana M.A., Meddens S.F., Linnér R.K., Rietveld C.A., Derringer J., Gratten J., Lee J.J., Liu J.Z., de Vlaming R., Ahluwalia T.S., Buchwald J., Cavadino A., Frazier-Wood A.C., Furlotte N.A., Garfield V., Geisel M.H., Gonzalez J.R., Haitjema S., Karlsson R., van der Laan S.W., Ladwig K.H., Lahti J., van der Lee S.J., Lind P.A., Liu T., Matteson L., Mihailov E., Miller M.B., Minica C.C., Nolte I.M., Mook-Kanamori D., van der Most P.J., Oldmeadow C., Qian Y., Raitakari O., Rawal R., Realo A., Rueedi R., Schmidt B., Smith A.V., Stergiakouli E., Tanaka T., Taylor K., Wedenoja J., Wellmann J., Westra H.J., Willems S.M., Zhao W., Amin N., Bakshi A., Boyle P.A., Cherney S., Cox S.R., Davies G., Davis O.S., Ding J., Direk N., Eibich P., Emeny R.T., Fatemifar G., Faul J.D., Ferrucci L., Forstner A., Gieger C., Gupta R., Harris T.B., Harris J.M., Holliday E.G., Hottenga J.J., De Jager P.L., Kaakinen M.A., Kajantie E., Karhunen V., Kolcic I., Kumari M., Launer L.J., Franke L., Li-Gao R., Koini M., Loukola A., Marques-Vidal P., Montgomery G.W., Mosing M.A., Paternoster L., Pattie A., Petrovic K.E., Pulkki-Råback L., Quaye L., Räikkönen K., Rudan I., Scott R.J., Smith J.A., Sutin A.R., Trzaskowski M., Vinkhuyzen A.E., Yu L., Zabaneh D., Attia J.R., Bennett D.A., Berger K., Bertram L., Boomsma D.I., Snieder H., Chang S.C., Cucca F., Deary I.J., van Duijn C.M., Eriksson J.G., Bültmann U., de Geus E.J., Groenen P.J., Gudnason V., Hansen T., Hartman C.A., Haworth C.M., Hayward C., Heath A.C., Hinds D.A., Hyppönen E., Iacono W.G., Järvelin M.R., Jöckel K.H., Kaprio J., Kardia S.L., Keltikangas-Järvinen L., Kraft P., Kubzansky L.D., Lehtimäki T., Magnusson P.K., Martin N.G., McGue M., Metspalu A., Mills M., de Mutsert R., Oldehinkel A.J., Pasterkamp G., Pedersen N.L., Plomin R., Polasek O., Power C., Rich S.S., Rosendaal F.R., den Ruijter H.M., Schlessinger D., Schmidt H., Svento R., Schmidt R., Alizadeh B.Z., Sørensen T.I., Spector T.D., Steptoe A., Terracciano A., Thurik A.R., Timpson N.J., Tiemeier H., Uitterlinden A.G., Vollenweider P., Wagner G.G., Weir D.R., Yang J., Conley D.C., Smith G.D., Hofman A., Johannesson M., Laibson D.I., Medland S.E., Meyer M.N., Pickrell J.K., Esko T., Krueger R.F., Beauchamp J.P., Koellinger P.D., Benjamin D.J., Bartels M., Cesarini D.
Collaborateur⸱rice⸱s
LifeLines Cohort Study
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Statut éditorial
Publié
Date de publication
06/2016
Peer-reviewed
Oui
Volume
48
Numéro
6
Pages
624-633
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Mots-clé
Anxiety Disorders/genetics, Bayes Theorem, Depression/genetics, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide
Pubmed
Web of science
Création de la notice
26/06/2016 14:26
Dernière modification de la notice
20/08/2019 14:32
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